2 documents found, page 1 of 1
Amifostine reduces inflammation and protects against 5-fluorouracil-induced ora...
Barbosa, Sabrina Carneiro Melo; Pereira, Venúcia B.M.; Wong, Deysi V.T.; Santana, Ana P.M.; Lucetti, Larisse T.; Carvalho, Lucas L.Oral mucositis (OM) is a common and dose-limiting side effect of cancer treatment, including 5-fluorouracil (5-FU) andradiotherapy. The efficacy of the therapeutic measures to prevent OM is limited and disease prevention is not fully observable.Amifostine is a cytoprotective agent with a described anti-inflammatory potential. It is clinically used to reduce radiotherapy andchemotherapy-associated xerostomia. Th...
Oral gabapentin treatment accentuates nerve and peripheralinflammatory response...
Câmara, Carlos C.; Ramos, Heitor F.; Silva, Alan P. da; Araújo, Celina V.; Gomes, Antoniella Souza; Vale, Mariana L.; Barbosa, André Luiz R.Gabapentin (GBP) is an anti-convulsive drug often used as analgesic to control neuropathic pain. Thisstudy aimed at evaluating whether oral GBP treatment could improve nerve inflammation response aftersciatic nerve constriction in association with selected pain and motor spontaneous behavior assessmentsin Wistar rats. We evaluated nerve myeloperoxidase (MPO) and inflammatory cytokines on the 5th daypost-injury,...