3 documents found, page 1 of 1
Pentoxifylline decreases glycemia levels and TNF-alpha, iNOS and COX-2 expressi...
Garcia, Francisca Adilfa O.; Pinto, Sofia F.; Cavalcante, Andrezza F.; Lucetti, Lívia T.; Menezes, Silvana M. S.; Felipe, Cícero Francisco B.Pentoxifylline (PTX), a methyl xanthine derivative, is a phosphodiesterase inhibitor with anti-inflammatory and renoprotective effects in diabetic patients, among other properties. We studied PTX actions and mechanisms in reducing blood biochemical parameters, in diabetic rats. For diabetes induction, alloxan was intravenously administered to male Wistar rats. One group was left untreated and the other ones tre...
Minocycline decreases blood glucose and triglyceride levels and reverses histol...
Viana, Glauce S. Barros; Pessoa, Igor X.; Ferreira, Pollyana L. Tavares; Carvalho, Antônio Germano G.; Garcia, Francisca Adilfa O.Increasing evidence suggests that oxidative stress and inflammation play major roles in diabetes mellitus and its complications. Furthermore, hyperg lycemia increases the produc tion of free radicals, resulting in oxidative stress. Minocycline presents potent anti-inflammatory and antioxidant activities, as evaluated by in vivo and in vitro models. In the present study, the minocycline anti-diabetic effect was ...
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms
Cruz, Giovany Michely Pinto da; Felipe, Cícero Francisco Bezerra; Scorza, Fúlvio Alexandre; Costa, Marta Aline Coelho da; Tavares, Alinne FariasPiperine, an alkaloid present in the Piper genus, was shown to have an anticonvulsant activity, evaluated by the pilocarpine-induced model, in mice. Pilocarpine (350 mg/kg, i.p.) was administered 30 min after piperine (2.5, 5, 10 and 20 mg/kg, i.p.) which significantly increased latencies to 1st convulsion and to death, and percentage of survivals. These parameters were also increased in the pilocarpine groups ...