2 documents found, page 1 of 1
Anti-inflammatory and anti-resorptive effects of atorvastatin on alveolar bone ...
Goes, Paula; Lima, Neiberg Alcântara; Rodrigues, José Ariévilo Gurgel; Benevides, Norma Maria Barros; Brito, Gerly Anne Castro; Lima, VilmaThe aim of this study was to evaluate the anti-inflammatory and anti-resorptive effect of atorvastatin (ATV) in an experimental alveolar bone loss (ABL) model. Wistar rats were subjected to ligature placement around the maxillary second molar for 11 days. The animals received 0.9% saline (2 mL/kg) or ATV (0.3, 3 or 27 mg/kg) daily by gavage. ABL was evaluated by resorption area and histopathological analysis. S...
Cyclooxygenase-2 expression on ifosfamide-induced hemorrhagic cystitis in rats
Macedo, Francisco Yuri Bulcao; Baltazar, Fátima; Almeida, Paulo Roberto Carvalho; Távora, Fábio; Ferreira, Francisco Valdeci; Schmitt, Fernando C.Purpose Hemorrhagic cystitis (HC) is a limiting side effect of chemotherapy with ifosfamide (IFS). In this study, we investigated the participation of cyclooxygenase-2 (COX-2) upon ifosfamide-induced HC. Methods Male Wistar rats (150-200 g; six rats per group) were treated with saline, IFS (400 mg/kg, i.p.) and analyzed by changes in bladder wet weight, macroscopic and microscopic parameters, and COX-2 expressi...