14 documents found, page 1 of 2
REDES MOLECULARES: UMA ANÁLISE SOBRE ANOTAÇÕES E DESCOBERTA DE NOVOS ATIVOS
Pilon,Alan C; Vieira,Natália C; Amaral,Juliano G; Monteiro,Afif F; Silva,Ricardo R. da; Spíndola,Laila S; Castro-Gamboa,Ian; Lopes,Norberto PMOLECULAR NETWORKS: AN ANALYSIS ON ANNOTATIONS AND DISCOVERY OF NEW ASSETS. To speed up the discovery of bioactive natural products (NP), chemists have sought advanced approaches in analytical and computational chemistry in attempt to organize and extract information from large data sets. In this sense, the molecular networks (MN) successfully organized enormous sets of mass spectrometry (MS) data together with...
METABOLÔMICA DE PLANTAS: MÉTODOS E DESAFIOS
Pilon,Alan C.; Selegato,Denise M.; Fernandes,Richard P.; Bueno,Paula C. P.; Pinho,Danielle R.; Carnevale Neto,Fausto; Freire,Rafael T.Metabolomics has played a central role in various areas of plant sciences, offering new perspectives for the advancement of agriculture, drug discovery, chemical ecology and taxonomy. Plant metabolomics (identification and quantification) aims to understand the relationship between biological systems and genetic, pathological and or environmental stimuli in terms of differential expression of the metabolism. Ow...
Update: Biological and Chemical Aspects of Senna spectabilis
Selegato,Denise M.; Monteiro,Afif F.; Vieira,Natália C.; Cardoso,Patrícia; Pavani,Victor D.; Bolzani,Vanderlan S.; Castro-Gamboa,IanSenna spectabilis (syn Cassia spectabilis) is one of the most important species within the Fabaceae family, natively found in Central and South America, as well as parts of Asia and Africa. Due to the extensive geographical distribution, this fast-growing tree produces a wide variety of bioactive secondary metabolites, being of special interest for chemical and pharmacological studies. Phytochemical investigati...
New Dereplication Method Applied to NMR-Based Metabolomics on Different Fusariu...
Selegato,Denise M.; Freire,Rafael T.; Tannús,Alberto; Castro-Gamboa,IanThe search for new sources of natural products steadily increased the use of bioinformatic tools that enabled efficient analysis of complex matrices. In this context, dereplication methods emerged as a fast way of identifying known compounds, accelerating the identification of bioactive chemotypes. Although 1H NMR is widely used as an analytical technique, few studies have been reported using it as a dereplicat...
Dereplication of phenolic derivatives of Qualea grandiflora and Qualea cordata ...
Carnevale Neto,Fausto; Siquitelli,Cristian D.; Pilon,Alan C.; Silva,Dulce H. S.; Bolzani,Vanderlan da S.; Castro-Gamboa,IanA rational and selective method using on-line high-performance liquid chromatography (HPLC) coupled with electrospray quadrupole time-of-flight tandem mass spectrometry (ESI-QToF-MS/MS) was established for the dereplication of phenolic derivatives from Qualea grandiflora and Qualea cordata. The selection of the extracts was based on the antioxidant capacity measured by in vitro DPPH assay. The HPLC-ESI-QToF-MS/...
Metabolômica, uma abordagem otimizada para exploração da biodiversidade brasile...
Funari,Cristiano Soleo; Castro-Gamboa,Ian; Cavalheiro,Alberto José; Bolzani,Vanderlan da SilvaBrazilian biodiversity is a colossal source of secondary metabolites with remarkable structural features, which are valuable in further biodiscovery studies. In order to fully understand the relations and interactions of a living system with its surroundings, efforts in natural product chemistry are directed toward the challenge of detecting and identifying all the molecular components present in complex sample...
Tropical biodiversity: has it been a potential source of secondary metabolites ...
Valli,Marilia; Pivatto,Marcos; Danuello,Amanda; Castro-Gamboa,Ian; Silva,Dulce Helena Siqueira; Cavalheiro,Alberto José; Araújo,Ângela ReginaThe use of natural products has definitely been the most successful strategy in the discovery of novel medicines. Secondary metabolites from terrestrial and marine organisms have found considerable use in the treatment of numerous diseases and have been considered lead molecules both in their natural form and as templates for medicinal chemistry. This paper seeks to show the great value of secondary metabolites...
Indole monoterpene alkaloids from Chimarrhis turbinata DC Prodr.: a contributio...
Cardoso,Carmen L.; Silva,Dulce Helena S.; Young,Maria Cláudia M.; Castro-Gamboa,Ian; Bolzani,Vanderlan da SilvaThe morphological parameters used to establish close connections among species taxonomically different into the Rubiaceae family is complex, mainly due to the lack of information on habitat and morphoanatomical characters in the lower hierarchic groups, for example, Chimarrhis genus. The micromolecular profile of delimited species into determined taxa can be useful to establish the boundaries among close taxono...
Constituintes químicos das flores de Pterogyne nitens (Caesalpinioideae)
Regasini,Luis Octávio; Fernandes,Daniara Cristina; Castro-Gamboa,Ian; Silva,Dulce Helena Siqueira; Furlan,Maysa; Bolzani,Vanderlan da SilvaThe phytochemical investigation of the flowers of Pterogyne nitens (Caesalpinioideae) resulted in the isolation and identification of nine phenolic derivatives, quercetin 3-O-sophoroside, taxifolin, astilbin, ourateacatechin, caffeic, ferulic, sinapic, chlorogenic and gallic acid, besides two guanidine alkaloids, pterogynine, pterogynidine. This is the first time these compounds have been reported in P. nitens ...
Saponinas antifúngicas de Swartzia langsdorffii
Marqui,Sara Regina de; Lemos,Renata Brionízio; Santos,Luciana Ávila; Castro-Gamboa,Ian; Cavalheiro,Alberto José; Bolzani,Vanderlan da SilvaChromatographic fractionation of the EtOH extract from the leaves of Swartzia langsdorffii afforded the pentacyclic triterpenes oleanolic acid and lupeol, and two saponins: oleanolic acid 3-sophoroside and the new ester 3-O-b-D-(6'-methyl)-glucopyranosyl-28-O-b-D-glucopyranosyl-oleanate. Their structures were elucidated from spectral data, including 2D NMR and HRESIMS experiments. Antifungal activity of all iso...