161 documents found, page 1 of 17

COVID-19 in a Tertiary Paediatric Centre in Portugal: a Single-Centre Retrospec...

Objective: To describe the demographic, clinical, laboratory and imaging features of the first 300 SARS-CoV-2-infected children presenting to a tertiary paediatric centre in Portugal. Design: Single-centre, retrospective, descriptive study of paediatric patients who had a confirmed SARS-CoV-2 infection from 7 March to 20 September 2020. Setting: Tertiary paediatric referral centre (Hospital Dona Estefânia, Lisb...

Diagnostic Challenge in a Sickle Cell Disease Patient with COVID-19

Acute chest syndrome is a life-threatening complication in sickle cell disease. Infections are frequently implied, and like other viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be a trigger. In addition, due to their inflammatory status, they may present a higher risk for severe coronavirus disease 2019 (COVID-19). Pneumonia and acute chest syndrome share clinical, laboratory, and rad...

Multisystem Inflammatory Syndrome in Children Associated with COVID-19 in a Ter...

Introduction: Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe manifestation of coronavirus disease 2019 (COVID-19). The aim of this study was to describe the characteristics of children with MIS-C admitted to a pediatric tertiary hospital in Portugal. Material and methods: Observational descriptive study of MIS-C patients admitted between April 2020 and April 2021. Demographic and cli...

Ketogenic Diet and Drug-Induced Hepatotoxicity During Tuberculosis Treatment

When therapy with hepatotoxic drugs is being considered, all other possible contributing agents of liver damage should be held to account. While not generally considered a risk factor, we present 2 cases in which ketogenic diet (KD) may have played a role in liver injury due to antituberculosis drugs. Ketogenic diet has been linked to liver injury, and while its pathophysiology remains obscure, carnitine deplet...

Tuberculose em Idade Pediátrica: Experiência de 12 Anos num Centro Terciário de...

Introduction: The diagnosis of tuberculosis in children is a challenge namely because extrapulmonary tuberculosis and severe disease are more frequent in this age group. The aim of this study was to evaluate and reflect about severe tuberculosis in pediatric age, in a metropolitan area of Lisbon. Material and methods: Descriptive study about patients under 18 years of age admitted with tuberculosis disease in a...

Protocol-Based Cardiotoxicity Monitoring in Hydroxychloroquine Medicated COVID-...

Introduction/objectives: By May 2020, SARS-CoV-2 had caused more than 400 000 deaths worldwide. Initially, hydroxychloroquine was a treatment option for COVID-19. More recent studies have questioned its safety and efficacy and, until stronger evidence is available, it was suspended from therapy protocols. We describe our experience treating COVID-19 Portuguese pediatric patients with hydroxychloroquine, having ...

Cardiac Injury and Vasoplegia in Critically ill Children due to Multisystem Inf...

Saliva Molecular Testing Bypassing RNA Extraction is Suitable for Monitoring an...

Background: Adults are being vaccinated against SARS-CoV-2 worldwide, but the longitudinal protection of these vaccines is uncertain, given the ongoing appearance of SARS-CoV-2 variants. Children remain largely unvaccinated and are susceptible to infection, with studies reporting that they actively transmit the virus even when asymptomatic, thus affecting the community. Methods: We investigated if saliva is an ...

Severe Mucositis Without a Rash Induced by a Mycoplasma Pneumoniae Infection

Rifampicin-Resistant Serotype B Neisseria meningitidis: First Case in Portugal