306 documents found, page 1 of 31
Film tourism and the image of the destination: preliminary impacts on host comm...
Liberato, Pedro; Sousa, Bruno; Brito, Miguel; Liberato, Dália; Santos, José DuarteIn recent decades, film tourism has expanded throughout the world. Increasingly, authors present the definitions, behaviors, and motivations of film tourists. Film tourism has a range of positive impacts, such as strengthening scenic beauty, reinforcing local pride, preserving local culture, conserving natural resources, attracting investment, improving local infrastructure, increasing the number of facilities,...
Newborn screening for sickle cell disease in Angola: implementation challenges ...
Brito, Miguel; Ginete, Catarina; Jacinto, Mariana; Mendes, Manuela; Soares, Hailton; Afonso, Roberto; Siatembo, Adriano; Vasconcelos, JocelyneSickle Cell Disease (SCD) is an autosomal recessive disorder with a substantial global burden. Despite its particularly high incidence in sub-Saharan Africa, early diagnosis remains limited in many countries. The objective of this study was to implement a newborn screening programme for SCD in one of the largest maternity hospitals in Angola and to support the subsequent pediatric follow-up of the affected chil...
The potential of DNA methylation as a biomarker for age-related macular degener...
Ghannai, Salema; Ribeiro, Edna; Pereira, Bruno; Brito, Miguel; Camacho, PedroAge-related macular degeneration (AMD) is a multifactorial disease influenced by genetic and environmental factors, yet its pathogenesis remains incompletely understood. DNA methylation, increasingly recognized as a disease indicator, has been linked to AMD and may represent a promising biomarker or therapeutic target. This systematic review, conducted according to PRISMA 2020 guidelines, analyzed 13 studies ad...
Prevalence and factors associated with inadequate intake of fruits and vegetabl...
Morais, Humberto; Cupessala, Vizé Preciosa; Pedro, João Mário; Brito, Miguel; Gonçalves, Mauer A. A.Background: The World Health Organization recommends a minimum intake of 400 g or five servings of Fruits and Vegetables (FVs) per day for the prevention of chronic diseases. Objective: The present study aims to describe the prevalence and factors associated with inadequate FV intake in a sample of Angolan adults who participated in the CardioBengo study. Methods: It is a subset analysis of CardioBengo, a commu...
Treating sickle cell disease in resource-limited sub-Saharan Africa: recent str...
Brito, Miguel; Ginete, Catarina; Ofakunrin, Akinyemi; Diaku-Akinwumi, Ijeoma; Inusa, Baba PsalmIntroduction: The management of Sickle cell disease (SCD) in sub-Saharan Africa (SSA) suffers from the lack of universal infant and population screening, inadequate access to standard treatment, and poor public health prioritization amidst unstable political systems. Areas covered: The state of evidence-based management of SCD in SSA was investigated, including the sustainability of international funding agenci...
Distribution of CCR5-Delta32, CCR2-64I, and SDF1-3’A host genetic factors in HI...
Sebastião, Cruz S.; Pimentel, Victor; Jandondo, Domingos; Sebastião, Joana M. K.; Sacomboio, Euclides; Pingarilho, Marta; Brito, MiguelBackground: The HIV/AIDS pandemic remains a public health concern. Studies on host genetic polymorphisms that confer resistance to HIV-1 infection or delay HIV disease progression are scarce in African countries. Herein, we investigate the proportion of the mutated phenotype of the AIDS-related polymorphisms CCR5-Delta32, CCR2-64I, and SDF1-3'A in HIV-infected and uninfected individuals in Luanda, the capital o...
Rotavirus alphagastroenteritidis: circulating strains after the introduction of...
Vita, Dikudila G.; Santiso-Bellón, Cristina; Lemos, Manuel; Neto, Zoraima; Fortes-Gabriel, Elsa; Brito, Miguel; Sebastião, Cruz S.Rotavirus alphagastroenteritidis (R. alphagastroenteritidis) remains the leading cause of pediatric diarrhea. Although Angola introduced Rotarix®, the human monovalent R. alphagastroenteritidis vaccine since 2014 as part of its routine childhood immunization program, no follow-up study has been conducted. This study aimed to evaluate the distribution of R. alphagastroenteritidis genotypes among children under f...
DNA methyltransferase expression (DNMT1, DNMT3a, and DNMT3b) as a potential bio...
Camacho, Pedro; Ribeiro, Edna; Pereira, Bruno; Nascimento, João; Rosa, Paulo Caldeira; Henriques, José; Barrão, Sandra; Sadio, Silvia; Quendera, BrunoBackground/Objectives: Age-related macular degeneration (AMD) is a global cause of vision loss, with limited therapeutic options highlighting the need for effective biomarkers. This study aimed to characterize plasma DNA methyltransferase expression (DNMT1, DNMT3A, and DNMT3B) in AMD patients and explore divergent expression patterns across different stages of AMD. Methods: Thirty-eight AMD patients were prospe...
Newborn screening for sickle cell disease in a hospital setting in Luanda, Ango...
Brito, Miguel; Ginete, Catarina; Mendes, Manuela; Afonso, Roberto; Siatembo, Adriano; Neto-Vasconcelo, Jocelyne; Inusa, BabaEarly diagnosis of Sickle Cell Disease (SCD) is critical to reducing mortality and morbidity in affected children; however, it remains largely unavailable in Sub-Saharan Africa, where disease prevalence is highest. This severe monogenic recessive disorder has an estimated mortality rate of 50–90% by age five if left undiagnosed. The Lancet Haematology Commission strongly recommends that all children worldwide b...
Exploring the link between gut microbiome and asthma risk in Angolan adults
Brito, Miguel; Arrais, Margarida; Delgadinho, Mariana; Ginete, Catarina; Dias, Welwitschia; Vasconcelos, JocelyneBackground: Asthma is one of the most prevalent chronic respiratory diseases worldwide, and although its prevalence is higher in high-income countries, most asthma-related deaths are in low- and middle-income countries. The lung and intestine are connected through intricate communication pathways that influence each other’s equilibrium. Metabolites generated by the gut microbiome, along with intestinal immune c...