5 documents found, page 1 of 1
The triterpenoid alpha, beta-amyrin prevents the impaired aortic vascular react...
Santos, Flávia Almeida; Batista-Lima, Francisco José; Nunes, Paulo Iury Gomes; Viana, Ana Flávia Seraine CustódioTo characterize the pro tective effects of the triterpenoid mixture alpha, beta-amyrin (AMY, 20 mg/kg, during 15 days) on the reactivity of isolated aorta of high- fat diet (HFD)-induced obese mice. Male Swiss mice were fed with HFD or normal diet (ND) for 15 weeks. Contractions of thoracic aorta in response to KCl or phen- ylephrine (PHE) and relaxation by acetylcholine (ACh) or sodium nitroprusside (SNP) were...
Metabolic acidosis aggravates experimental acute kidney injury
Magalhães, Patrícia Andréa da Fonseca; Brito, Teresinha Silva de; Freire, Rosemayre Souza; Silva, Moisés Tolentino Bento da; Santos, Armênio Aguiar dosims Ischemia/reperfusion (I/R) injury and metabolic acidosis (MA) are two critical conditions that may simultaneously occur in clinical practice. The result of this combination can be harmful to the kidneys, but this issue has not been thoroughly investigated. The present study evaluated the influence of low systemic pH on various parameters of kidney function in rats that were subjected to an experimental mode...
Atividade vasorrelaxante do 2-nitro-1-fenil-1-propanol em preparações vasculare...
Brito, Teresinha Silva de2-Nitro-1-phenyl-1-propanol (NPP) is a nitro-alcohol used as a chemical intermediate in the synthesis of ephedrine and norephedrine, sympathomimetic agonists. Its chemical structure resembles the norephedrine, with replacement of the NH2 group by NO2. The presence of the nitro group led us to consider that this compound is able of produce vasodilatory effect, since it was demonstrated in a previous study the va...
Vasodilatação causada pelo 1-nitro-2-feniletano em aorta de rato : provável est...
Brito, Teresinha Silva deIt was early shown that intravenous treatment with 1-nitro-2-phenylethane (NPE) induced hypotension resulting mainly from its direct vasodilatory action on vascular smooth muscle. Here, it was sudied the underlying mechanism involved in the vasorelaxant effect of NPE in isolated rings of rat arteries. Isometric recordings were obtained from rings made from aorta or mesenteric artery using a digital acquisition ...
Talking about bioelectrical potentials using rings of the mesenteric artery wit...
Ribeiro-Filho, Helder Veras; Brito, Teresinha Silva de; Lima, F. J. B.; Pinho, J. P. M.; Sousa, D. F.; Silva, Moisés Tolentino Bento daIn the present study, a practical activity is proposed to adopt an experimental approach to demonstrate the relationship between the equilibrium potential for K and transmembrane electrical potential without glass micropipettes. A conventional setup for recording contractile activity of isolated smooth muscle preparations was used based on the events elegantly described by Somlyo and Somlyo in the 1960s. They s...