8 documents found, page 1 of 1
Role of the route of leukotrienes in an experimental model of oral mucositis in...
Silva,Viviane Carvalho da; Leitão,Renata Ferreira de Carvalho; Brito,Gerly Anne de Castro; Martins,Conceição da Silva; Freire,Gildenio EstevamAbstract Purpose: To investigate the participation of cysteinyl leukotrienes in the pathophysiology of oral mucositis. Methods: Oral mucositis was induced in hamsters using 5-fluorouracil (5-FU; 60 and 40 mg/kg; i.p., on days 1 and 2, respectively, and with excoriations in jugal mucosa on day 4). Montelukast (10, 20, or 40 mg/kg/d; gavage), MK886 (3 mg/kg/d, i.p.), or saline or celecoxib (7.5 mg/kg/d; i.p.) was...
Study of the protective effect of dexamethasone on cisplatin-induced ototoxicit...
Capelo,Isabelle Oliveira Jatai; Batista,Avner Marcos Alves; Brito,Yuri Neyson Ferreira; Diniz,Krissia Braga; Brito,Gerly Anne de CastroAbstract Purpose: To evaluate the ability of dexamethasone to protect against cisplatin (CDDP)-induced ototoxicity. Methods: Male Wistar rats were divided into the following three groups: 1) Control (C): 6 animals received intraperitoneal (IP) saline solution, 8 ml/kg/day for four days; 2) C + CDDP: 11 animals received 8 ml/kg/day of IP saline and, 90 min after saline administration, 8 mg/kg/day of IP CDDP for ...
Oil mixes omega 9, 6 and 3, enriched with seaweed, promoted reduction of therma...
Campelo,Ana Paula Bomfim Soares; Campelo,Márcio Wilker Soares; Brito,Gerly Anne de Castro; Jamacaru,Francisco Vagnaldo FechinePURPOSE: To examine the effects of the oil mixes (ω-9, ω-6 and ω-3) in rats subjected to thermal burn. It was also aimed to assess whether the sources of ω3 would interfere with the effect of such mixes on the thermal injury.METHODS:Thirty-six rats distributed into five groups: burned + water, burned + isolipid mix, burned + oil mix 1 (ALA), burned + oil mix 2 (ALA + EPA + DHA of fish) and burned + oil mix 3 (A...
Electroacupuncture ameliorates experimental colitis induced by TNBS through act...
Goes,Annya Costa Araujo de Macedo; Pinto,Francisco Maxwell Martins; Fernandes,Guilherme Cardoso; Barbosa,Jessica Sales; Correia,Emanuela SantosPURPOSE: To study the anti-inflammatory actions of electroacupuncture (EAc) on an experimental colitis model in mice. METHODS: Thirty-eight male Swiss mice, divided in five groups, were subjected to induction of colitis by TNBS in 50% ethanol. Saline (SAL) and ethanol (ETNL) groups served as controls. TNBS+EAc and TNBS+ dexamethasone subgroups were treated with EAc 100Hz and dexamethasone (DEXA) 1 mg/Kg/day, re...
Changes in morphology of long bone marrow tissue of rats submitted to cryothera...
Costa,Fábio Wildson Gurgel; Pessoa,Rosana Maria Andrade; Nogueira,Carlos Bruno Pinheiro; Pereira,Karuza Maria Alves; Brito,Gerly Anne de CastroPURPOSE: To study the main effects of local use of liquid nitrogen on bone marrow tissue in rats. METHODS: The femoral diaphyses of 42 Wistar rats were exposed to three local and sequential applications of liquid nitrogen for one or two minutes, intercalated with periods of five minutes of passive thawing. The animals were sacrificed after one, two, four and 12 weeks and the specimens obtained were analyzed his...
Histomorphometric assessment of bone necrosis produced by two cryosurgery proto...
Costa,Fábio Wildson Gurgel; Brito,Gerly Anne de Castro; Pessoa,Rosana Maria Andrade; Studart-Soares,Eduardo CostaOBJECTIVE: The aim of this study was to evaluate the effects of liquid nitrogen cryosurgery on the femoral diaphysis of rats. MATERIAL AND METHODS: The femoral diaphyses of 42 Wistar rats were exposed to three local and sequential applications of liquid nitrogen for 1 or 2 min, intercalated with periods of 5 min of passive thawing. The animals were sacrificed after 1, 2, 4 and 12 weeks and the specimens obtaine...
Effect of a combination of medium chain triglycerides, linoleic acid, soy lecit...
Magalhães,Maria Sonia Felício; Fechine,Francisco Vagnaldo; Macedo,Rafael Nogueira de; Monteiro,Diego Levi Silveira; Oliveira,Cecília CarvalhoPURPOSE: The aim of the study was to determine the effect of a combination of medium chain triglycerides (caprylic, capric, caproic and lauric acids), linoleic acid (essential fatty acid), vitamins A and E and soy lecithin, through a morphometric study, on the wound healing kinetics of experimental cutaneous ulcers. METHODS: A total of 45 male Wistar rats were used, in which a skin flap of total thickness with ...
Effect of soluble fiber or fructooligosaccharide supplementation upon trinitrob...
Murad-Regadas,Sthela Maria; Souza,Marcellus Henrique Loiola Ponte de; Brito,Gerly Anne de Castro; Rodrigues,Lusmar VerasPURPOSE: To evaluate the effect of soluble fiber or fructooligosaccharide (FOS) supplementation upon trinitrobenzene sulphonic acid (TNBS)-induced colitis in rats. METHODS: 64 Wistar rats were given water, soluble fiber or FOS intragastrically during 14 days prior to colitis induction with TNBS (n=48) or rectal enema with water (n=16; control group). On the 7th or 14th day following colitis induction the rats w...