4 documents found, page 1 of 1
Phylogeography of hepatitis B virus: the role of Portugal in the early dissemin...
Marcelino, Rute; Ezeonwumelu, Ifeanyi Jude; Janeiro, André; Mimoso, Paula; Matos, Sónia; Briz, Veronica; Pimentel, Victor; Pingarilho, MartaIn Portugal, the genetic diversity, origin of HBV and the Portuguese role in the dissemination of HBV worldwide were never investigated. In this work, we studied the epidemic history and transmission dynamics of HBV genotypes that are endemic in Portugal. HBV pol gene was sequenced from 130 patients followed in Lisbon. HBV genotype A was the most prevalent (n = 54, 41.5%), followed by D (n = 44, 33.8%), and E (...
Phylogeography of hepatitis B virus : the role of Portugal in the early dissemi...
Marcelino, Rute; Ezeonwumelu, Ifeanyi Jude; Janeiro, André; Mimoso, Paula; Matos, Sónia; Briz, Veronica; Pimentel, Victor; Pingarilho, MartaIn Portugal, the genetic diversity, origin of HBV and the Portuguese role in the dissemination of HBV worldwide were never investigated. In this work, we studied the epidemic history and transmission dynamics of HBV genotypes that are endemic in Portugal. HBV pol gene was sequenced from 130 patients followed in Lisbon. HBV genotype A was the most prevalent (n = 54, 41.5%), followed by D (n = 44, 33.8%), and E (...
A Conserved GPG-Motif in the HIV-1 Nef Core Is required for principal nef-activ...
Martínez-Bonet, Marta; Palladino, Claudia; Briz, Veronica; Rudolph, Jochen M.; Fackler, Oliver T.; Relloso, Miguel; Muñoz-Fernandez, Maria AngelesTo find out new determinants required for Nef activity we performed a functional alanine scanning analysis along a discrete but highly conserved region at the core of HIV-1 Nef. We identified the GPG-motif, located at the 121–137 region of HIV-1 NL4.3 Nef, as a novel protein signature strictly required for the p56Lck dependent Nef-induced CD4-downregulation in T-cells. Since the Nef-GPG motif was dispensable fo...
Predictors of attrition and immunological failure in HIV-1 patients on highly a...
Palladino, Claudia; Briz, Veronica; Bellón, José María; Bártolo, Inês; Carvalho, Patrícia; Camacho, Ricardo; Muñoz-Fernández, M. Ángeles; Bastos, RuiIn Mozambique, the evaluation of retention in HIV care and ART programmes is limited. To assess rate and predictors of attrition (no retention in care) and HAART effectiveness in HIV-1 infected patients who pay for medication and laboratory testing in Mozambique, we conducted a multicenter survey of HIV-1-infected patients who started HAART during 2002–2006. Cox proportional hazard models were used to assess ri...