6 documents found, page 1 of 1
Contribution of the carbohydrate-binding ability of Vatairea guianensis lectin ...
Marques, Gabriela Fernandes Oliveira; Osterne, Vinicius José Silva; Almeida, Livia M.; Oliveira, Messias Vital; Brizeno, Luiz André CavalcanteVatairea guianensis lectin (VGL), Dalbergiae tribe, is a N-acetyl-galactosamine (GalNAc)/Galactose (Gal) lectin previously purified and characterized. In this work, we report its structural features, obtained from bioinformatics tools, and its inflammatory effect, obtained from a rat paw edema model. The VGL model was obtained by homology with the lectin of Vatairea macrocarpa (VML) as template, and we used it ...
Análise proteômica de saliva de pacientes com lesões potencialmente malignas e ...
Brizeno, Luiz André CavalcanteOral cancer is a serious public health problem in Brazil. The most common histological type of malignancy in the oral cavity (90 to 95% of cases) is squamous cell carcinoma (SCC) an invasive and aggressive epithelial neoplasia and low survival mainly due to late diagnosis. Eventually, lesions that precede the appearance of malignant neoplasias, called potentially malignant lesions (PML), may occur, being oral l...
TNF-alpha expression, evaluation of collagen, and TUNEL of Matricaria recutita ...
Oliveira, Bruna Vasconcelos; Silva, Paulo Goberlânio de Barros; Nojosa, Jacqueline Santiago; Brizeno, Luiz André Cavalcante; Ferreira, Jamile MagalhãesOBJECTIVES: Characterize the cell profile and immunostaining of proinflammatory markers in an experimental model of bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIALS AND METHODS: Male Wistar rats (n = 6– 7) were treated chronically with saline solution or zoledronic acid (ZA) at 0.04, 0.20, and 1.00 mg kg 1 (1.4 3 10 7, 6.9 3 10 6, and 3.4 3 10 5 mol kg 1), and subsequently, the first left inferio...
Immune cellular profile of bisphosphonate-related osteonecrosis of the jaw
Silva, Paulo Goberlândio de Barros; Oliveira, C. C. de; Brizeno, Luiz André Cavalcante; Wong, Deysi V. T.; Lima Júnior, Roberto César PereiraOBJECTIVES: Characterize the cell profile and immunostaining of proinflammatory markers in an experimental model of bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIALS AND METHODS: Male Wistar rats (n = 6-7) were treated chronically with saline solution or zoledronic acid (ZA) at 0.04, 0.20, and 1.00 mg kg(-1) (1.4 × 10(-7) , 6.9 × 10(-6) , and 3.4 × 10(-5) mol kg(-1) ), and subsequently, the fir...
Immune cell profile of dental pulp tissue treated with zoledronic acid
Silva, Paulo Goberlânio de Barros; Verde, Maria Elisa Quezado Lima; Brizeno, Luiz André Cavalcante; Wong, Deysi V. T.Abstract Immune cell profile of dental pulp tissue treated with zoledronic acid. International Endodontic Journal. Aim To characterize the pulp immune cell profile in the teeth of rats treated with zoledronic acid (ZA). Methodology Male Wistar rats (n = 6 per group) received four intravenous infusions of ZA at doses of 0.04, 0.20 or 1.00 mg kg 1 ZA or saline (control). On the 70th experimental day, they were euth...
Chronic treatment with zoledronic acid increases inflammatory markers in period...
Silva, Paulo Goberlânio de Barros; Ferreira Junior, Antonio Ernando Carlos; Oliveira, Camila Carvalho de Oliveira; Brizeno, Luiz André CavalcanteBackground: Bisphosphonates (BF) rise proinflammatory markers and irreversibly bind to bone. Chronically, BF can lead to an inflammatory status and can increase the local oxidative stress in periodontium. Therefore, the objective of this study was to evaluate whether the chronic infusion of Zoledronic Acid (ZA) increases inflam- matory markers in periodontium of rats. Methods and results: Chronically, infusion ...