3 documents found, page 1 of 1
Colon tumor CD31 expression is associated with higher disease-free survival in ...
Silva, Ana; Pereira, Sofia S.; Brandão, José Ricardo; Brochado, Paulo; Monteiro, Mariana P.; Araújo, António; Faria, GilMetabolic syndrome (MS) is recognized as a risk factor for colon cancer (CC). However, how does the interplay between metabolic dysfunction caused by MS and its individual components affect CC microenvironment and prognosis remains unexplored. Angiogenesis and lymphangiogenesis are fundamental processes for tumor progression and dissemination, ensuring oxygen and nutrient delivery and supporting one of the most...
Congenital heart defects in isolated and syndromic context
Silva, Cátia; Varela, Catarina; Almeida, Cláudia; Gomes, Marcos; Brochado, Paulo; Nogueira, RoseteCongenital heart defects (CHD) is defined as a coarse structural abnormality of the heart or intrathoracic large vessels and which has functional significance. The objectives of this study were to determine the percentage of CHD in fetal autopsies and its frequency in isolated and syndromic context evaluate the most frequent types of CHD and determine the impact of histological study in the diagnosis of cardiac...
In vivo and in vitro effects of RAD001 on bladder cancer
Vasconcelos-Nóbrega, Carmen; Pinto-Leite, Rosário; Arantes-Rodrigues, Regina; Ferreira, Rita; Brochado, Paulo; Cardoso, Maria L.; Palmeira, CarlosObjective: To evaluate the influence of Everolimus (RAD001) on chemically induced urothelial lesions in mice and its influence on in vitro human bladder cancer cell lines. Methods: ICR male mice were given N-butyl-N-(4-hydroxybutyl) nitrosamine in drinking water for a period of 12 weeks. Subsequently, RAD001 was administered via oral gavage, for 6 weeks. At the end of the experiment, all the animals were sacrif...