3 documents found, page 1 of 1
Copper acts synergistically with fluconazole in Candida glabrata by compromisin...
Gaspar-Cordeiro, Ana; Amaral, Catarina; Pobre, Vânia; Antunes, Wilson; Petronilho, Ana; Paixão, Paulo; Matos, António P.; Pimentel, CatarinaThe synergistic combinations of drugs are promising strategies to boost the effectiveness of current antifungals and thus prevent the emergence of resistance. In this work, we show that copper and the antifungal fluconazole act synergistically against Candida glabrata, an opportunistic pathogenic yeast intrinsically tolerant to fluconazole. Analyses of the transcriptomic profile of C. glabrata after the combina...
The role of the Yap5 transcription factor in remodeling gene expression in resp...
Pimentel, Catarina; Vicente, Cristina; Menezes, Regina Andrade; Caetano, Soraia; Carreto, Laura; Rodrigues-Pousada, ClaudinaThe budding yeast Saccharomyces cerevisiae has developed several mechanisms to avoid either the drastic consequences of iron deprivation or the toxic effects of iron excess. In this work, we analysed the global gene expression changes occurring in yeast cells undergoing iron overload. Several genes directly or indirectly involved in iron homeostasis showed altered expression and the relevance of these changes a...
Characterization and expression analysis of the aspartic protease gene family o...
Pimentel, Catarina; Straeten, Dominique Van Der; Pires, Euclides; Faro, Carlos; Rodrigues-Pousada, ClaudinaCardosin A and cardosin B are two aspartic proteases mainly found in the pistils of cardoon Cynara cardunculus L., whose flowers are traditionally used in several Mediterranean countries in the manufacture of ewe's cheese. We have been characterizing cardosins at the biochemical, structural and molecular levels. In this study, we show that the cardoon aspartic proteases are encoded by a multigene family. The ge...