2 documents found, page 1 of 1
Living Proof of Activity of Extracellular Vesicles in the Central Nervous System
Mahjoum, Shadi; Rufino-Ramos, David; Almeida, Luís Pereira de; Broekman, Marike L. D.; Breakefield, Xandra O.; van Solinge, Thomas S.The central nervous system (CNS) consists of a heterogeneous population of cells with highly specialized functions. For optimal functioning of the CNS, in disease and in health, intricate communication between these cells is vital. One important mechanism of cellular communication is the release and uptake of extracellular vesicles (EVs). EVs are membrane enclosed particles actively released by cells, containin...
Glioblastoma hijacks microglial gene expression to support tumor growth
Maas, Sybren L. N.; Abels, Erik R.; Van De Haar, Lieke L.; Zhang, Xuan; Morsett, Liza; Sil, Srinjoy; Guedes, Joana; Sen, Pritha; Prabhakar, ShilpaBackground: Glioblastomas are the most common and lethal primary brain tumors. Microglia, the resident immune cells of the brain, survey their environment and respond to pathogens, toxins, and tumors. Glioblastoma cells communicate with microglia, in part by releasing extracellular vesicles (EVs). Despite the presence of large numbers of microglia in glioblastoma, the tumors continue to grow, and these neuroimm...