2 documents found, page 1 of 1
Multimodal MRI analysis of basal forebrain structure and function across the Al...
Herdick, Meret; Dyrba, Martin; Fritz, Hans-Christian J.; Altenstein, Slawek; Ballarini, Tommaso; Brosseron, Frederic; Buerger, KatharinaBackground: Dysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alz- heimer’s disease (AD). Multimodal MRI allows for the investigation of cBF changes in-vivo. In this study we assessed alterations in cBF functional connectivity (FC), mean diffusivity (MD), and volume across the spectrum of AD. We further assessed effects of amyloid pathology on these changes. Methods: P...
The Central Biobank and Virtual Biobank of BIOMARKAPD: A Resource for Studies o...
Reijs, Babette L R; Teunissen, Charlotte E; Goncharenko, Nikolai; Betsou, Fay; Blennow, Kaj; Baldeiras, Inês; Brosseron, Frederic; Cavedo, EnricaBiobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of body fluid markers for the diagnosis and prognosis of Alzheimer's disease (AD) and Parkinson's disease (PD). The objective was...