3 documents found, page 1 of 1
Deep brain stimulation of the anterior nucleus of the thalamus in drug-resistan...
Peltola, Jukka; Colon, Albert J.; Pimentel, José; Coenen, Volker A.; Gil-Nagel, Antonio; Gonçalves Ferreira, António; Lehtimäki, Kai; Ryvlin, PhilippeBackground and objectives: The efficacy of deep brain stimulation of the anterior nucleus of the thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated in the double-blind Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy randomized controlled trial. The Medtronic Registry for Epilepsy (MORE) aims to understand the safety and longer-term effectiveness of ANT DBS therap...
Awakening: Predicting external stimulation to force transitions between differe...
Deco, Gustavo; Cruzat, Josephine; Cabral, Joana; Tagliazucchi, Enzo; Laufs, Helmut; Logothetis, Nikos K.; Kringelbach, Morten L.A fundamental problem in systems neuroscience is how to force a transition from one brain state to another by external driven stimulation in, for example, wakefulness, sleep, coma, or neuropsychiatric diseases. This requires a quantitative and robust definition of a brain state, which has so far proven elusive. Here, we provide such a definition, which, together with whole-brain modeling, permits the systematic...
Perturbation of whole-brain dynamics in silico reveals mechanistic differences ...
Deco, Gustavo; Cabral, Joana; Saenger, Victor M.; Boly, Melanie; Tagliazucchi, Enzo; Laufs, Helmut; Van Someren, Eus; Jobst, Beatrice; Stevner, AngusHuman neuroimaging research has revealed that wakefulness and sleep involve very different activity patterns. Yet, it is not clear why brain states differ in their dynamical complexity, e.g. in the level of integration and segregation across brain networks over time. Here, we investigate the mechanisms underlying the dynamical stability of brain states using a novel off-line in silico perturbation protocol. We ...