9 documents found, page 1 of 1
SARS-CoV-2 infection in the immediate post-transplant period: A report of five ...
Sousa,Luís Leite de; Santos,Afonso; Lima,Anna; Nascimento,Célia; Jorge,Cristina; Bruges,Margarida; Adragão,Teresa; Weigert,AndréABSTRACT Introduction: The severe acute respiratory syndrome coronavirus 2 pandemic caused a negative impact on transplantation worldwide. One of the complexities is the management of the immunosuppression and anti-viral medication in transplant recipients. Herein we describe our experience managing five patients with coronavirus disease 2019 (COVID-19) immediately after kidney transplant. Description: we descr...
SARS-CoV-2 infection in kidney transplant recipients: clinical impact and outco...
Santos,Afonso; Sousa,Luís Leite de; Calça,Rita; Lima,Anna; Nascimento,Célia; Jorge,Cristina; Adragão,Teresa; Bruges,Margarida; Peres,SusanaABSTRACT Introduction: Kidney transplant recipients are a subgroup of patients at higher risk of critical forms of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection and poor outcomes due to immunosuppression treatment. Herein, we present data from a single center cohort of kidney transplant recipients with SARS-CoV-2 infection. Methods: In a prospective study, baseline characteristics, clin...
Therapeutic plasma exchange in the treatment of severe hypertriglyceridemia: a ...
Carvalho,Tiago J; Martins,Ana Rita; Calça,Rita; Torres,João Sousa; Gil,Célia; Rodrigues,Ilídio; Gaspar,Maria Augusta; Adragão,Teresa; Bruges,MargaridaSevere hypertriglyceridemia is defined as a serum triglyceride level >885mg/dl. It is an uncommon condition associated with serious complications, mainly acute pancreatitis. Treatment includes lifestyle changes, medical therapy and, more recently, extracorporeal apheresis techniques. Herein, we report a case of severe hypertriglyceridemia managed with therapeutic plasma exchange. Our patient presented with seve...
Are cranberry capsules effective and safe in preventing urinary tract infection...
Pereira,Tiago Assis; Fernandes,Ana Raquel; Mendes,Artur; Oliveira,Regina; Casqueiro,Ana; Birne,Rita; Matias,Patrícia; Jorge,Cristina; Adragão,TeresaIntroduction: Kidney transplant (KT) recipients are highly susceptible to urinary tract infections (UTIs). Few data are available regarding the effects of cranberry products in KT recipients. Subjects and methods: This was a randomized double-blind study comparing daily treatment with a cranberry capsule versus a placebo capsule for 6 months. The study protocol was conducted in accordance with the Helsinki Decl...
Pregnancy in renal transplanted patients: effects on the mother and the newborn...
Cândido,Cristina; Viegas,Márcio; Matias,Patrícia; Birne,Rita; Jorge,Cristina; Weigert,André; Adragão,Teresa; Bruges,Margarida; Machado,DomingosBackground: Chronic kidney disease causes decreased fertility. With kidney transplantation, fertility is restored within a few months. Objective: To analyse the feasibility of pregnancy with renal transplantation and its impact on renal function, complications in women and newborns. Methods: Retrospective study of pregnancies that occurred in kidney transplant recipients between 1985 and 2014 in one Transplanta...
Mineral and Bone Disease (MBD)
Birne,Rita; Adragão,Teresa; Ferreira,Aníbal; Dickson,Jorge; Silva,Rui; Casqueiro,Ana; Oliveira,Regina; Martins,Ana Rita; Torres,João; Matias,PatríciaA 50-year-old post-menopausal recipient of a kidney allograft with bone pain, osteoporosis, persistent hypercalcaemia and elevated parathormone (PTH) levels, despite a satisfactory graft function, was treated with bisphosphonates and cinacalcet starting, respectively, 5 and 6 months after renal transplantation (RT). Sixteen months after treatment, there was improvement of bone mineral density (BMD) measured by ...
Inhibitors of the mammalian target of rapamycin in kidney transplantation: impa...
Farinha,Ana; Matias,Patrícia; Jorge,Cristina; Bruges,Margarida; Adragão,Teresa; Birne,Rita; Weigert,André; Machado,DomingosBackground: Inhibitors of the mammalian target of rapamycin (mTOR) have demonstrated a similar outcome on allograft loss but its impact on patient survival has only recently been evaluated. In this outcome analysis all renal transplants performed at our unit since 1/1/2006 until 12/31/2011, were evaluated. Allograft failure and mortality were compared between patients who were converted to mTOR and those who re...
Renal transplantation in an HIV-2 positive recipient in Portugal
Natário,Ana; Rodrigues,Bruno; Matias,Patrícia; Jorge,Cristina; Bruges,Margarida; Birne,Rita; Miranda,Ana; Mansinho,Kamal; Machado,DomingosThe improvement of combined antiretroviral therapy regimens has made solid organ transplantation a therapeutic option for patients with human immunodeficiency virus (HIV) infection. Generally, HIV-2 infectionpresents a slower clinical progression and immunological degradation than HIV-1. HIV-2 infection treatment can be challenging when a complex immunosuppressive regimen is combined with antiretroviraltherapy....
Bortezomib in the treatment of refractory kidney graft rejection
Farinha,Ana; Jorge,Cristina; Weigert,André; Bruges,Margarida; Birne,Rita; Matias,Patrícia; Adragão,Teresa; Machado,DomingosBackground. Bortezomib, a 26S proteasome inhibitor, is a novel treatment for refractory acute rejection. The main mechanism proposed for its action is the induction of apoptosis of mature plasma cells leading to an interruption of donor-specific antibody production, but other properties may also be involved. Patients and Methods. Four patients presenting with antibody-mediated rejection were treated with bortez...