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Persistence of the ABCC6 genes and the emergence of the bony skeleton in verteb...

Parreira, Bruna; Cardoso, João; Costa, Rita; Couto, Ana Rita; Bruges-Armas, Jacome; Power, Deborah M.

The ATP-binding cassette transporter 6 (ABCC6) gene encodes a cellular transmembrane protein transporter (MRP6) that is involved in the regulation of tissue calcification in mammals. Mutations in ABCC6 are associated with human ectopic calcification disorders. To gain insight into its evolution and involvement in tissue calcification we conducted a comparative analysis of the ABCC6 gene and the related gene ABC...


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