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Acute blockade of endogenous melatonin by Luzindole, with or without peripheral...

Matos,R.S.; Oriá,R.B.; Bruin,P.F.C.; Pinto,D.V.; Viana,A.F.S.C.; Santos,F.A.; Duarte,A.S.G.; Bruin,V.M.S.

This study investigated the acute blockade of endogenous melatonin (MLT) using Luzindole with or without systemic lipopolysaccharide (LPS) challenge and evaluated changes in inflammatory and oxidative stress markers in the mouse jejunum. Luzindole is an MT1/MT2 MLT receptor antagonist. Both receptors occur in the small intestine. Swiss mice were treated with either saline (0.35 mg/kg, ip), Luzindole (0.35 mg/kg...

Date: 2021 | Origin: Oasisbr

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