6 documents found, page 1 of 1
Renal involvement in paroxysmal nocturnal haemoglobinuria: a brief review of th...
Macedo,Ênio Simas; Parente Filho,Sérgio Luiz Arruda; Pro,Juan Daniel Zuñiga; Rolim,Victor de Matos; Primo,Guilherme de Alencar SalazarSUMMARY INTRODUCTION: Paroxysmal Nocturnal Haemoglobinuria (PNH) is an acquired genetic disorder characterized by complement-mediated haemolysis, thrombosis and variable cytopenias. Renal involvement may occur and causes significant morbidity to these patients. OBJECTIVE: To review the literature about pathophysiology and provide recommendations on diagnosis and management of renal involvement in PNH. METHODS: ...
Sickle cell disease and pregnancy: analysis of 34 patients followed at the Regi...
Silva-Pinto,Ana Cristina; Ladeira,Simery de Oliveira Domingues; Brunetta,Denise Menezes; Santis,Gil Cunha De; Angulo,Ivan de Lucena; Covas,Dimas TadeuObjective: The objective of this study was to verify the evolution of pregnancies in sickle cell patients followed at one institution over a period of 12 years (January 2000 to June 2012). Methods: The study evaluated 34 pregnant women with sickle cell disease with a mean age of 23.9 ± 5.3 years. The incidence of obstetric complications, non-obstetric complications linked to sickle cell disease and complication...
Clinical and hematological effects of hydroxyurea therapy in sickle cell patien...
Silva-Pinto,Ana Cristina; Angulo,Ivan Lucena; Brunetta,Denise Menezes; Neves,Fabia Idalina Rodrigues; Bassi,Sarah Cristina; Santis,Gil Cunha DeCONTEXT AND OBJECTIVES Sickle cell disease (SCD) is the most common genetic disorder among people of African descent, affecting approximately 3,500 newborns each year in Brazil. Hydroxyurea (HU) is the only effective drug to treating patients with SCD, thereby reducing morbidity and mortality. The objective was to analyze the effects of HU on SCD patients at our institution. DESIGN AND SETTING Retrospective stu...
Hematological particularities and co-infections in injected drug users with AIDS
Brunetta,Denise Menezes; De Santis,Gil Cunha; Vilar,Fernando Crivelenti; Brandão,Renata Amorim; Muniz,Renata Zomer de AlbernazHIV patients infected through injected drug use have poorer prognosis than other groups. We evaluated the hematological alterations and rates of co-infections in injected drug use patients with AIDS. Injected drug use patients were younger, predominantly of male gender, and presented lower CD4, total lymphocyte, and platelet counts, but not neutrophil count, than control group. Injected drug use patients had a ...
Hematological differences between patients with different subtypes of sickle ce...
Neves,Fabia; Menezes Neto,Osvaldo Alves; Polis,Larissa Bueno; Bassi,Sarah Cristina; Brunetta,Denise Menezes; Silva-Pinto,Ana CristinaOBJECTIVE: Sickle cell anemia and the interaction S/Beta thalassemia differ in hematological values due to microcytosis and hypochromia caused by the thalassemic mutation. The clinical benefit of long-term hydroxyurea treatment is undeniable in sickle cell disease with monitoring of the biological action of the drug being by the complete blood count. The objective of this work is to compare changes in some of t...
Rhabdomyolysis and acute renal failure after strenuous exercise and alcohol abu...
Daher,Elizabeth De Francesco; Silva Júnior,Geraldo Bezerra da; Brunetta,Denise Menezes; Pontes,Lícia Borges; Bezerra,Glaydcianne PinheiroCONTEXT: Rhabdomyolysis is a severe and life-threatening condition in which skeletal muscle is damaged. Acute renal failure due to rhabdomyolysis has been widely described and its main pathophysiological mechanisms are renal vasoconstriction, intraluminal cast formation and direct myoglobin toxicity. OBJECTIVE: To report on a case of acute renal failure (ARF) induced by rhabdomyolysis due to strenuous exercise ...