2 documents found, page 1 of 1
Interaction of a Homologous Series of Amphiphiles with P-glycoprotein in a Memb...
Moreno, Maria João; Filipe, Hugo A. L.; Cunha, Susana V. P.; Ramos, Cristiana V.; Martins, Patricia A. T.; Abel, Biebele; Loura, Luís M. S.The transport of drugs by efflux transporters in biomembranes limits their bioavailability and is a major determinant of drug resistance development by cancer cells and pathogens. A large number of chemically dissimilar drugs are transported, and despite extensive studies, the molecular determinants of substrate specificity are still not well understood. In this work, we explore the role of polar and non-polar ...
Imaging of photoacoustic-mediated permeabilization of giant unilamellar vesicle...
Pereira, Diogo A.; Silva, Alexandre D.; Martins, Patricia A. T.; Piedade, A. P.; Martynowych, Dmitro; Veysset, David; Moreno, Maria João; Serpa, CarlosTarget delivery of large foreign materials to cells requires transient permeabilization of the cell membrane without toxicity. Giant unilamellar vesicles (GUVs) mimic the phospholipid bilayer of the cell membrane and are also useful drug delivery vehicles. Controlled increase of the permeability of GUVs is a delicate balance between sufficient perturbation for the delivery of the GUV contents and damage to the ...