7 documents found, page 1 of 1
Antidepressant effects of a single dose of ayahuasca in patients with recurrent...
Osório,Flávia de L.; Sanches,Rafael F.; Macedo,Ligia R.; dos Santos,Rafael G.; Maia-de-Oliveira,João P.; Wichert-Ana,Lauro; de Araujo,Draulio B.Objectives: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. Methods: Open-label trial conducted in an inpatient psychiatric unit. R...
New molecular targets for PET and SPECT imaging in neurodegenerative diseases
Benadiba,Marcel; Luurtsema,Gert; Wichert-Ana,Lauro; Buchpigel,Carlos Alberto; Busatto Filho,GeraldoThe pathophysiology of neurodegenerative diseases (ND) such as Alzheimer's disease (AD) and Parkinson's disease (PD) has not yet been completely elucidated. However, in the past few years, there have been great knowledge advances about intra-and extracellular proteins that may display impaired function or expression in AD, PD and other ND, such as amyloid beta (Aβ), α-synuclein, tau protein and neuroinflam...
Mortality in children with severe epilepsy: 10 years of follow-up
Terra,Vera C.; Scorza,Fulvio A.; Arida,Ricardo M.; Fernandes,Regina M.F.; Wichert-Ana,Lauro; Machado,Helio R.; Sakamoto,Américo C.Epilepsy is the main neurological condition in children and adolescents. Unfortunately patients with medical refractory epilepsy are more susceptible for clinical complications and death. We report a prospectively evaluated cohort of children followed for approximately 10 years. Fifty-three of 1012 patients died. Forty-two patients died due to epilepsy or its clinical complications and the main causes of death ...
Neurovascular coupling and functional neuroimaging in epilepsy
Becker Junior,Valesio; Wichert-Ana,Lauro; Silva,Rhelen Piantino Leitão Ferreira da; Abud,Daniel Giansante; Escorsi-Rosset,Sara; Romcy-Pereira,RodrigoINTRODUCTION: The neural regulation of the microcirculation is done by the functional neurovascular unit that is composed of vascular, astroglial and neuronal cells. The neurovascular unit represents the interface between the Central Nervous System and the Vascular System. OBJECTIVE: This paper reviews the literature on functional neuroimaging with a particular focus on the mechanisms of the neurovascular coupl...
Variable fMRI activation during two different language tasks in a patient with ...
Escorsi-Rosset,Sara; Wichert-Ana,Lauro; Bianchin,Marino Muxfeldt; Velasco,Tonicarlo Rodrigues; Sakamoto,Américo C.; Leite,João PereiraFunctional MRI produces a more accurate localization of the language areas for epilepsy surgery purpose, but requires the patient cooperation. We report a 34 years-old woman with mental retardation who underwent two different verbal fluency tasks, category and word naming. We found a strong activation of the Brocas area in the most difficult task. We suggest that a multi-task fMRI study could be successful in ...
Epistaxis during a generalized seizure leading to an atypical ictal SPECT findi...
Wichert-Ana,Lauro; Ferruzzi,Emerson Henklain; Alexandre Jr,Veriano; Velasco,Tonicarlo Rodrigues; Bianchin,Marino MuxfeldtINTRODUCTION: Generalized tonic-clonic seizures (GTCS) are among the most dramatic types of epileptic seizures and may be accompanied by rising blood pressure and pulse rate, physical injuries from falling, muscular convulsions, tongue biting, or aspiration pneumonia. Epistaxis is an uncommon complication of generalized seizures and investigations should exclude local or systemic disorders. OBJECTIVE: We aim to...
Hiperamonemia secundária ao uso terapêutico de ácido valpróico: relato de caso
Turcato,Marlene de Fátima; Fernandes,Regina Maria França; Wichert-Ana,Lauro; Funayama,Carolina Araújo RodriguesO ácido valpróico tem sido amplamente utilizado no tratamento da epilepsia, sendo usualmente bem tolerado, não obstante alguns efeitos colaterais que lhe são atribuídos. Um efeito ainda pouco conhecido é a hiperamonemia, independente da hepatotoxicidade da droga. A hiperamonemia se estabelece no início ou no decurso do tratamento, sendo caracterizada por vômitos, alteração progressiva da consciência, sinais neu...