22 documents found, page 1 of 3

Implementation of a Pilot Study to Analyze Circulating Tumor DNA in Early-Stage...

Introduction: Liquid biopsies based on plasma circulating tumour deoxyribonucleic acid (ctDNA) have shown promise in monitoring lung cancer evolution. The expression of ctDNA across time, its relationship with clinicopathological parameters and its association with lung cancer progression through imaging allow us to weigh how useful ctDNA could be in monitoring surgically resectable lung cancer. The aim of this...

Portuguese Consensus Recommendations for Next-Generation Sequencing of Lung Can...

Next-generation sequencing (NGS) has been implemented in clinical oncology for diagnosis, prognosis, and therapeutic guidance. Among the various NGS applications in molecular oncology, we focused on the following topics: laboratory standards for targeted gene panels (somatic mutations) and therapeutic guidance based on NGS of lung cancer and rare cancers, namely sarcomas and cancers of unknown primary. Multiple...

The Influence of the Genetic and Immunologic Context in the Development of Colo...

Introduction: Overcoming immunosurveillance is a major step in the progression of many types of tumors. Several immune escape strategies have been identified, including immunoediting and the establishment of an immune suppressive microenvironment. The aim of the present study was to determine whether the hereditary or sporadic context has any influence in the relationship between immune surveillance and tumor d...

Molecular characterization of Portuguese patients with dilated cardiomyopathy

Introduction: Dilated cardiomyopathy (DCM) is a disease of the heart muscle characterized by ventricular dilatation and impaired systolic function. Familial forms account for 30-50% of cases. Autosomal dominant inheritance is the predominant pattern of transmission. Causal genetic variants have been identified in several genes and molecular diagnosis has implications for genetic counseling and risk stratificati...

Targeted Gene Next-Generation Sequencing Panel in Patients with Advanced Lung A...

Identification of targetable molecular changes is essential for selecting appropriate treatment in patients with advanced lung adenocarcinoma. Methods: In this study, a Sanger sequencing plus Fluorescence In Situ Hybridization (FISH) sequential approach was compared with a Next-Generation Sequencing (NGS)-based approach for the detection of actionable genomic mutations in an experimental cohort (EC) of 117 pati...

Docosahexaenoic acid loaded lipid nanoparticles with bactericidal activity agai...

Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid present in fish oil, has been described as a promising molecule to the treatment of Helicobacter pylori gastric infection. However, due to its highly unsaturated structure, DHA can be easily oxidized loosing part of its bioactivity. This work aims the nanoencapsulation of DHA to improve its bactericidal efficacy against H. pylori. DHA was loaded ...

A PERSPETIVA DO LABORATÓRIO

A NOVEL MISSENSE MUTATION IN THE ALPHATROPOMYOSIN (TPM1) GENE IN A FAMILY AFFEC...

ARRHYTHMIC RISK AND GENETIC VARIATIONS IN DILATED CARDIOMYOPATHY PATIENTS

CLINICAL AND PROGNOSTIC PROFILE OF PATIENTS WITH DILATED CARDIOMYOPATHY CAUSED ...