27 documents found, page 1 of 3
Diagnosis and management of acromegaly: a consensus statement of the pituitary ...
Cardoso, Luís Miguel; Marques, Pedro; Pereira, Maria Teresa; Agapito, Ana; Almeida, Rui; Amaral, Sara; Cattoni, Maria Begona; Bugalho, Maria JoãoAcromegaly is characterised by hypersecretion of growth hormone and presents diagnostic and therapeutic challenges that require consensus and guidelines for effective management. The Pituitary Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism used a modified Delphi methodology to develop consensus recommendations for the diagnosis and management of acromegaly. A multidisciplinary p...
Comparative Cyto-Histological Genetic Profile in a Series of Differentiated Thy...
Matos, Maria de Lurdes; Pinto, Mafalda; Alves, Marta; Canberk, Sule; Gonçalves, Ana; Bugalho, Maria João; Papoila, A.L.; Soares, PaulaFunding Information: This research received funding for SC, in the framework of a Ph.D. grant (SFRH/BD/147650/2019) supported by Portuguese funds through Fundação para a Ciência e a Tecnologia (FCT). This study is part of the project “Institute for Research and Innovation in Health Sciences” (UID/BIM/04293/2019) and the project “The Porto Comprehensive Cancer Center” ref. NORTE-01-0145-FEDER-072678—Consórcio PO...
Choristoma: a very rare cause of thyroid nodule: case report and literature review
Rocha, José Vicente; Cruz, Rafael Moiteiro Da; Alexandre, Maria Inês; Gomes, Ana Raquel; Lopez-Presa, Dolores; Bugalho, Maria JoãoBackground: Choristoma is a well-defined benign lesion formed by histologically normal tissue in an unusual location. Diagnosis is confirmed after surgical removal of the mass. To our knowledge, to date there has been only one case of thyroid choristoma described in the literature. Patient findings: A 70-year-old man with a history of non-Hodgkin lymphoma presented with sudden cervical enlargement. Cervical CT ...
Factors for second non-diagnostic ultrasound-guided fine-needle aspiration cyto...
Cosme, Inês; Nobre, Ema; Bugalho, Maria JoãoIntroduction: Results in fine-needle aspiration cytology (FNAC) of thyroid nodules may be non-diagnostic (ND). In these cases, it is recommended to repeat the FNAC. The aim of our study was to evaluate the influence of demographic, clinical and ultrasound (US) characteristics in the recurrence of an ND result in thyroid nodule FNAC. Methods: A retrospective study of ND thyroid nodule FNAC was performed for the ...
Usefulness of a clinicopathological classification in predicting treatment-rela...
Peixe, Carolina; Alexandre, Maria Inês; Gomes, Ana Raquel; Nobre, Ema; Silva, Ana Luísa; Oliveira, Tiago; Lopez-Presa, Dolores; Faria, ClaudiaPurpose: A clinicopathological classification has been designed to predict recurrence/progression in patients with pituitary adenomas (PAs). We aimed to study its usefulness in predicting PAs that will have a challenging disease course and may require more often complex multimodal and multiple therapeutic approaches. Methods: Retrospective analysis of 129 patients with PAs operated in our institution between 20...
Adherens Junction Integrity Is a Critical Determinant of Sodium Iodide Symporte...
Faria, Márcia; Vareda, José; Miranda, Micaella; Bugalho, Maria João; Silva, Ana Luísa; Matos, PauloWhile most cases of differentiated thyroid carcinoma (DTC) are associated with a good prognosis, a significant number progress to advanced disease exhibiting aggressive clinical characteristics and often becoming refractory to radioactive iodine (RAI) treatment, the current gold-standard therapeutic option for metastatic disease. RAI-refractoriness is caused by defective functional expression of the sodium-iodi...
Different antibody-associated autoimmune diseases have distinct patterns of T f...
Ribeiro, Filipa; Romão, Vasco C.; Rosa, Sara; Jesus, Kátia; Agua-Doce, Ana; Barreira, Sofia; Martins, Patrícia; Silva, Susana; Nobre, EmaAutoantibodies are produced within germinal centers (GC), in a process regulated by interactions between B, T follicular helper (Tfh), and T follicular regulatory (Tfr) cells. The GC dysregulation in human autoimmunity has been inferred from circulating cells, albeit with conflicting results due to diverse experimental approaches. We applied a consistent approach to compare circulating Tfr and Tfh subsets in pa...
The microenvironment of pituitary adenomas: biological, clinical and therapeuti...
Marques, Pedro; Silva, Ana Luísa; López Presa, Dolores; Faria, Claudia; Bugalho, Maria JoãoThe microenvironment of pituitary adenomas (PAs) includes a range of non-tumoral cells, such as immune and stromal cells, as well as cell signaling molecules such as cytokines, chemokines and growth factors, which surround pituitary tumor cells and may modulate tumor initiation, progression, invasion, angiogenesis and other tumorigenic processes. The microenvironment of PAs has been actively investigated over t...
Connective tissue disease as a cause of discrepant capillary and serum glucose ...
Matos, Tânia; Rocha, José Vicente; Barreira, Sofia; Vale, Sónia do; Bugalho, Maria JoãoCapillary glucose measurement is widely used for point-of-care testing and for self-monitoring of blood glucose. Nevertheless, fingertip capillary glucose assessment has some limitations and could lead to erroneous estimations in several situations, such as problems associated with certain medications or conditions related to hyperviscosity or to impaired capillary blood flow.
MAPK Inhibition Requires Active RAC1 Signaling to Effectively Improve Iodide Up...
Faria, Márcia; Domingues, Rita; Bugalho, Maria João; Matos, Paulo; Silva, Ana LuísaThe Sodium/Iodide Symporter (NIS) is responsible for the active transport of iodide into thyroid follicular cells. Differentiated thyroid carcinomas (DTCs) usually preserve the functional expression of NIS, allowing the use of radioactive iodine (RAI) as the treatment of choice for metastatic disease. However, a significant proportion of patients with advanced forms of TC become refractory to RAI therapy and no...