3 documents found, page 1 of 1
Copaifera langsdorffii: evaluation of potential gastroprotective of extract and...
Lemos,Marivane; Santin,José Roberto; Mizuno,Cassia Suemi; Boeing,Thaise; Sousa,João Paulo Barreto de; Nanayakkara,Dhammika; Bastos,Jairo KenuppAbstractGastric ulcer is a prevalent gastrointestinal disease, and the drugs currently used in the treatment produce several adverse effects. In this context, the search for new therapeutic antiulcer agents is essential, and medicinal plants have great potential. Here, we investigated the gastroprotective properties of Copaifera langsdorffii Desf., Fabaceae, hydroalcoholic extract obtained from leaves and its i...
Validation of an hplc method for the determination of 1,7-dihydroxy-2,3-methyle...
Klein-Júnior,Luiz Carlos; Andrade,Sérgio Faloni de; Cechinel-Filho,Valdir; Bresolin,Tania Mari BelléPolygala cyparissias is a plant widespread in Southern Latin America. Recently, we demonstrated the gastroprotective activity of the extract, as well as for one of the isolated metabolites-1,7-dihydroxy-2,3-methylenedioxyxanthone (MDX). In this study, a HPLC method for the quantification of MDX was validated. The HPLC method was linear (0.5-24 µg mL-1 of MDX) with good accuracy, precision and robustness. The co...
Evaluation of the in vivo mutagenic potential of hydroalcoholic extracts of the...
Freitas,Patrícia Scotini; Andrade,Sérgio Faloni de; Maistro,Edson LuisThe northern highbush blueberry (Vaccinium corymbosum L. Ericales, Ericaceae) is very rich in anthocyanins, natural pigments which have strong antioxidant properties and potential health benefits, resulting in the worldwide use the blueberry as a medicinal plant. We investigated the mutagenic potential of simple hydroalcoholic extracts of V. corymbosum acutely administrated by gavage to Swiss mice at doses of 1...