2 documents found, page 1 of 1
Analysis of shared heritability in common disorders of the brain
Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose; Duncan, Laramie; Escott-Price, ValentinaDisorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common varian...
An empirical study of the typology of bulimic symptoms in young Portuguese women
Pinheiro, Andrea Poyastro; Bulik, Cynthia M.; Sullivan, Patrick F.; Machado, Paulo P. P.Objective: To investigate whether clusters of bulimic symptoms exist in a community sample of young Portuguese women. Method: A total of 2028 females, aged 12–23 years, completed the Eating Disorder Examination Questionnaire (EDE-Q). Latent class analysis was applied to the seven bulimic symptoms, age, and body mass index. Results: The selected 4-class solution yielded a ‘‘healthy’’ class, reporting minimal bin...