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Epidermal Barrier Dysfunction in Atopic Dermatitis

Gomes,Tiago Fernandes; Calado,Rebeca; Gonçalo,Margarida

ABSTRACT Impaired skin barrier is one of the hallmarks of atopic dermatitis (AD), with abnormalities in the cornified envelope, lipid lamellae, tight junctions and cutaneous microbiome. These findings are also present in nonlesional skin of AD individuals, suggesting that epidermal barrier defects may be the initial step towards the development of AD and eventually other atopic diseases (atopic march). It is cu...

Date: 2021   |   Origin: SciELO Portugal

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