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Kinase inhibition in relapsed/refractory leukemia and lymphoma settings: recent...
Machado, Caio Bezerra; Pessoa, Flávia Melo Cunha de Pinho; Silva, Emerson Lucena da; Pantoja, Laudreísa da Costa; Ribeiro, Rodrigo MonteiroCancer is still a major barrier to life expectancy increase worldwide, and hematologic neoplasms represent a relevant percentage of cancer incidence rates. Tumor dependence of continuous proliferative signals mediated through protein kinases overexpression instigated increased strategies of kinase inhibition in the oncologic practice over the last couple decades, and in this review, we focused our discussion on...
The miRNA profile of platelets stored in a blood bank and its relation to cellu...
Pontes, Thaís Brilhante; Moreira-Nunes, Caroline de Fátima Aquino; Maués, Jersey Heitor da Silva; Lamarão, Letícia MartinsMillions of blood products are transfused each year, and many lives are directly affected by transfusion. Platelet concentrate (PC) is one of the main products derived from blood. Even under good storage conditions, PC is likely to suffer cell damage. The shape of platelets changes after 5 to 7 days of storage at 22°C. Taking into consideration that some platelet proteins undergo changes in their shape and func...