2 documents found, page 1 of 1
The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tum...
Badenes, Marina; Burbridge, Emma; Oikonomidi, Ioanna; Amin, Abdulbasit; de Carvalho, Érika; Kosack, Lindsay; Mariano, Camila; Domingos, PedroFunding Information: The authors thank the Animal Facility, the Histopathology, the Advanced Imaging, and Flow cytometry units and the antibody service of the Instituto Gulbenkian de Ciência. We thank Cristina Branco for reagents and Sarah Maguire for advice about expression correlation analysis. We thank Colin Crump (Cambridge, UK) for providing the HSV-1 DNA. We thank Stefan Rose-John and Cristina Branco for ...
Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metal...
Cavadas, Miguel; Oikonomidi, Ioanna; Gaspar, Catarina J.; Burbridge, Emma; Badenes, Marina; Félix, Inês; Bolado, Alfonso; Hu, Tianyi; Bileck, AndreaCell surface metalloproteases coordinate signaling during development, tissue homeostasis, and disease. TACE (TNF-α-converting enzyme), is responsible for cleavage (“shedding”) of membrane-tethered signaling molecules, including the cytokine TNF, and activating ligands of the EGFR. The trafficking of TACE within the secretory pathway requires its binding to iRhom2, which mediates the exit of TACE from the endop...