4 documents found, page 1 of 1
Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High...
Burgeiro, Ana; Cerqueira, Manuela G.; Varela-Rodríguez, Bárbara M; Nunes, Sara; Neto, Paula; Pereira, Frederico C.; Reis, Flávio; Carvalho, EugeniaGlucotoxicity and lipotoxicity are key features of type 2 diabetes mellitus, but their molecular nature during the early stages of the disease remains to be elucidated. We aimed to characterize glucose and lipid metabolism in insulin-target organs (liver, skeletal muscle, and white adipose tissue) in a rat model treated with a high-sucrose (HSu) diet. Two groups of 16-week-old male Wistar rats underwent a 9-wee...
Altered mitochondrial epigenetics associated with subchronic doxorubicin cardio...
Ferreira, André; Cunha-Oliveira, Teresa; Simões, Rui F.; Carvalho, Filipa S.; Burgeiro, Ana; Nordgren, Kendra; Wallace, Kendall B.; Oliveira, Paulo J.Doxorubicin (DOX), a potent and broad-spectrum antineoplastic agent, causes an irreversible, cumulative and dose-dependent cardiomyopathy that ultimately leads to congestive heart failure. The mechanisms responsible for DOX cardiotoxicity remain poorly understood, but seem to involve mitochondrial dysfunction on several levels. Epigenetics may explain a portion of this effect. Since mitochondrial dysfunction ma...
Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to...
Carvalho, Filipa S.; Burgeiro, Ana; Garcia, Rita; Moreno, Antonio J.; Carvalho, Rui A.; Oliveira, Paulo J.Doxorubicin (DOX) is an anticancer anthracycline that presents a dose-dependent and cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have been advanced to explain DOX cardiac side effects, which culminate in the development of life-threatening cardiomyopathy. One of the most studied mechanisms involves the activation of DOX molecule into a more reactive semiquinone by mitoch...
Complex Formation between Heptakis(2,6-di-O-methyl)-β-cyclodextrin and Cyclopen...
Pereira, Cláudia C. L.; Diogo, Cátia V.; Burgeiro, Ana; Oliveira, Paulo J.; Marques, M. Paula M.; Braga, Susana S.; Paz, Filipe A. AlmeidaThe inclusion compounds isolated from nonaqueous solutions of heptakis(2,6-di-O-methyl)-β-cyclodextrin (DIMEB) and the complexes [CpMoL2(CO)2](BF4) (L = MeCN, L2 = 2,2′-biimidazole) were characterized in the solid state by powder X-ray diffraction (XRD), thermogravimetric analysis (TGA), 13C{1H} CP/MAS NMR, and FTIR spectroscopy. Powder XRD showed that the compound with [CpMo(MeCN)2(CO)2](BF4) was amorphous, wh...