Colorectal câncer is the fifth most common type of câncer in Brazil and the incidence is growing in developed countries. The earliest preneoplastic lesion presenting dysplasia is aberrant crypt foci (ACF), a precursor of colorectal adenoma and câncer in humans. Knowledge of ACF formation is crucial to understanding the mechanisms involved in colorectal câncer and their inhibition. The objective of this study wa...
Colorectal cancer has a high incidence and is known to be influenced by dietary factors. The fatty acids -3, -6 and -9 are believed to be involved in its genesis and prevention. The objective was to evaluate the effect of hyperlipidic, normolipidic and hypolipidic diets with low -6:-3 ratio and high -9:-6 ratio on azoxymethane (AOM) induced colorectal carcinogenesis in rats. Sixty 3-week-old male Wistar ...
Objetivo: Avaliar as repercussões hepáticas da carcinogênese colônica induzida por diferentes doses e tempos de exposição ao azoximetano em ratos Wistar. Métodos: Quarenta e quatro ratos foram distribuídos em quatro grupos. Os animais tinham oito semanas no início do experimento. No grupo 1, receberam 1.0mL de solução salina intraperitonealmente uma vez por semana por duas semanas. No grupo 2, receberam 15 mg/k...
PURPOSE: To assess weight changes in rats fed diets with different ratios of omegas 3, 6 and 9 submitted to colonic carcinogenesis induced by Azoxymethane (AOM). METHODS: Sixty rats with three weeks of life were distributed into five groups of specific diets containing 12 animals each: GIStandard diet without adminstration of AOM, GII- Standard diet with adminstration of AOM; GIII– Hyperlipidic diet with admins...