6 documents found, page 1 of 1
New Cu(II) complexes with pyrazolyl derived schiff base ligands: synthesis and ...
Ribeiro, Nadia; Roy, Somnath; Butenko, Nataliya; Cavaco, Isabel; Pinheiro, Teresa; Alho, Irina; Marques, Fernanda; Avecilla, FernandoSince the discovery of cisplatin there has been a continuous pursuit for new metallodrugs showing higher efficacies and lower side effects. In this work, new copper(II) complexes (C1-C6) of Schiff bases derived from pyrazolyl were developed. Through condensation of 5-methyl-1H-pyrazole-3-carbohydrazide with different aromatic aldehydes - pyridoxal, salicylaldehyde, 3-methoxy-2-hydroxybenzaldehyde, 3-ethoxy-2-hy...
Formation and properties of sediments in constructed wetlands for treatment of ...
Vergeles, Yuriy; Butenko, Nataliya; Ishchenko, Andriy; Stolberg, Felix; Hogland, Marika; Hogland, WilliamSediments formation and biogeochemical properties were studied in an experimental constructed wetland site in Ukraine (Bioplato) for treatment of domestic effluents. The wetland, with a capacity of 50m(3) d(-1) of wastewater, consists of vertical and horizontal filtrations units with fine gravel, middle and coarse sand, a subsurface flow unit with natural wetland soil applied, and a septic tank and sludge-dryin...
Interaction of vanadium compounds with DNA
Butenko, NataliyaThe DNA cleavage activity of several vanadium complexes (VC) was studied. The focus was on vanadium acetylacetonate, VIVO(acac)2, 1, and several β-diketonate oxidovanadium(IV/V) derivatives: VIVO(hd)2 (2, hd = 3,5-heptanedione), VIVO(Cl-acac) 2, (3, Cl-acac = 3-chloro-2,4-pentanedione), VIVO(Et-acac)2 (4, Et-acac = 3-ethyl- 2,4- pentanedione) and VIVO(Me-acac)2 (5, Me-acac = 3-methyl-2,4-pentanedione), VV2O4(ac...
Antioxidant, DNA cleavage, and cellular effects of silibinin and a new oxovanad...
Naso, Luciana G.; Ferrer, Evelina G.; Butenko, Nataliya; Cavaco, Isabel Maria Palma Antunes; Lezama, Luis; Rojo, Teófilo; Etcheverry, Susana B.A new complex of the oxovanadium(IV) cation with the flavolignan silibinin has been synthesized and characterized. Vanadium compounds show interesting biological and pharmacological properties and some of them display antitumoral actions. Flavonoids are part of a larger group of antioxidant compounds called polyphenols which may inhibit the proliferation and growth of cancer cells. The antioxidant and antitumor...
Cyto- and genotoxicity of a vanadyl(IV) complex with oxodiacetate in human colo...
Di Virgilio, Ana L.; Rivadeneira, Josefina; Muglia, Cecilia I.; Reigosa, Miguel A.; Butenko, Nataliya; Cavaco, Isabel Maria Palma AntunesThe complex of vanadyl(IV) cation with oxodiacetate, VO(oda) caused an inhibitory effect on the proliferation of the human colon adenocarcinoma cell line Caco-2 in the range of 25–100 lM (P\0.001). This inhibition was partially reversed by scavengers of free radicals. The difference in cell proliferation in the presence and the absence of scavengers was statistically significant in the range of 50–100 lM (P\0.0...
DNA cleavage activity of VIVO(acac)2 and derivatives
Butenko, Nataliya; Tomaz, Ana Isabel; Nouri, Ofelia; Escribano, Esther; Moreno, Virtudes; Gama, Sofia; Ribeiro, Vera; Telo, João PauloThe DNA cleavage activity of several b-diketonate vanadyl complexes is examined. Vanadyl acetylacetonate,VIVO(acac)2, 1, shows a remarkable activity in degrading plasmid DNA in the absence of any activating agents, air and photoirradiation. The cleaving activity of several related complexes VIVO(hd)2(2, Hhd = 3,5-heptanedione), VIVO(acac-NH2)2 (3, Hacac-NH2 = acetoacetamide) and VIVO(acac-NMe2)2(4, Hacac-NMe2 =...