Encontrados 2 documentos, a visualizar página 1 de 1
Efeito antidepressivo do dimetil fumarato em camundongos submetidos ao modelo d...
Souza, Alana Gomes deMajor Depressive Disorder (MDD) is a highly prevalent psychiatric condition. Many patients are not responsive to conventional pharmacotherapy that modulates the monoaminergic system and even those who are responsive have various adverse effects. Dimethyl fumarate (DMF) is an activator of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, which has antioxidant and anti-inflammatory effects. As sever...
Antioxidant properties of antiepileptic drugs levetiracetam and clonazepam in m...
Oliveira, Aline de Albuquerque; Linhares, Maria Isabel; Chaves Filho, Adriano José Maia; Rios, Emiliano Ricardo VasconcelosThis study aimed to investigate the in vitro antioxidant activity of the novel anticonvulsant levetiracetam and benzodiazepine clonazepam. To do this, the mice brain homogenates were incubated with levetiracetam (50, 100 or 200 g/ml) or clonazepam (50, 100 or 200 g/ml), and then, submitted to heating at 37°C for 1 h. Ascorbic acid (vitamin C, 200 g/ml) was used as reference antioxidant drug. The markers of o...