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Oral gabapentin treatment accentuates nerve and peripheralinflammatory response...
Câmara, Carlos C.; Ramos, Heitor F.; Silva, Alan P. da; Araújo, Celina V.; Gomes, Antoniella Souza; Vale, Mariana L.; Barbosa, André Luiz R.Gabapentin (GBP) is an anti-convulsive drug often used as analgesic to control neuropathic pain. Thisstudy aimed at evaluating whether oral GBP treatment could improve nerve inflammation response aftersciatic nerve constriction in association with selected pain and motor spontaneous behavior assessmentsin Wistar rats. We evaluated nerve myeloperoxidase (MPO) and inflammatory cytokines on the 5th daypost-injury,...
Date: 2014
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Origin: Oasisbr