2 documents found, page 1 of 1
Role of regulatory T cells in irinotecan-induced intestinal mucositis
Fernandes, Camila; Wanderley, Carlos Wagner Souza; Silva, Camila Meireles Souza; Muniz, Heitor Amorim; Teixeira, Maraiza AlvesIntestinal mucositis (IM) is a common side effect of irinotecan-based chemotherapy. The involvement of inflammatory mediators, such as TNF-α, IL1-β, IL-18 and IL-33, has been demonstrated. However, the role of adaptive immune system cells, whose activation is partially regulated by these cytokines, is yet unknown. Thus, we investigated the role of regulatory T cells (Tregs) in irinotecan-induced IM. C57BL/6 mic...
Increased frequency of CD4 and CD8 regulatory T cells in individuals under 15 y...
Fernandes, Camila; Gonçalves, Heitor Sá; Cabral, Paula Brito e; Pinto, Helena Câmara; Pinto, Maria Isabel Moraes; Câmara, Lilia Maria CarneiroBackground: Leprosy is a chronic disease, caused by Mycobacterium leprae, which poses a serious public health problem worldwide. Its high incidence in people under 15 years old in Ceara´ state, Brazil, reflects the difficulty of its control. The spectrum of clinical manifestations is associated with the immune response developed, with the Th1 and Th2 responses being related to the paucibacillary and multibacill...