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Role of regulatory T cells in irinotecan-induced intestinal mucositis

Fernandes, Camila; Wanderley, Carlos Wagner Souza; Silva, Camila Meireles Souza; Muniz, Heitor Amorim; Teixeira, Maraiza Alves

Intestinal mucositis (IM) is a common side effect of irinotecan-based chemotherapy. The involvement of inflammatory mediators, such as TNF-α, IL1-β, IL-18 and IL-33, has been demonstrated. However, the role of adaptive immune system cells, whose activation is partially regulated by these cytokines, is yet unknown. Thus, we investigated the role of regulatory T cells (Tregs) in irinotecan-induced IM. C57BL/6 mic...

Date: 2018   |   Origin: Oasisbr
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