8 documents found, page 1 of 1
Clinical trial for uniform multidrug therapy for leprosy patients in Brazil (U-...
Cruz, Rossilene Conceição da Silva; Bührer-Sékula, Samira; Penna, Gerson Oliveira; Moraes, Maria Elisabete Amaral de; Gonçalves, Heitor de SáBACKGROUND: The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil (U-MDT/CT-BR), designed to evaluate the effectiveness of a six-months regimen, assessed the adverse effects caused by the drugs. OBJECTIVE: Describe adverse effects due to MDT in U-MDT/CT-BR, comparing the uniform regimen (U-MDT) to the current WHO regimen (R-MDT). Patients and methods: After operational classification, ...
Genotyping comparison of Mycobacterium leprae isolates by VNTR analysis from na...
Lima, Luana Nepomuceno Costa; Frota, Cristiane Cunha; Suffys, Philip Noel; Fontes, Amanda Nogueira Brum; Mota, Rosa Maria SalaniConselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico, Brazil under [grant number CNPq?410573/2006-0].; Federal University of Cear?. Faculdade de Medicina. Departamento de Patologia e Medicina Legal. Fortaleza, CE, Brazil / Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.; Federal University of Cear?. Faculdade de Medicina. Departamento de Patolog...
Uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): results...
Penna, Gerson Oliveira; Bührer-Sékula, Samira; Kerr, Ligia Regina Franco Sansigolo; Rodrigues, Laura Cunha; Araújo, Marcelo Grossi deBackground Leprosy control is based on early diagnosis and multidrug therapy. For treatment purposes, leprosy patients can be classified as paucibacillary (PB) or multibacillary (MB), according to the number of skin lesions. Studies regarding a uniform treatment regimen (U-MDT) for all leprosy patients have been encouraged by the WHO, rendering disease classification unnecessary. Methodology and findings An ind...
Detection of subclinical Mycobacterium leprae infection in children, contacts o...
Louren?o, Delaide Sampaio Dias; Campelo, Thales Alves; Cruz, Gizele Almada; Almeida, Paulo Cesar de; Gon?alves, Heitor de S?Federal University of Cear?. School of Medicine. Department of Pathology and Legal Medicine. Fortaleza, CE, Brazil.; Federal University of Cear?. School of Medicine. Department of Pathology and Legal Medicine. Fortaleza, CE, Brazil.; Federal University of Cear?. School of Medicine. Department of Pathology and Legal Medicine. Fortaleza, CE, Brazil.; Cear? State University. Center for Health Sciences. Fortaleza,C...
Presence of Mycobacterium leprae genotype 4 in environmental waters in Northeas...
Holanda, Maísa Viana de; Marques, Livia Erika Carlos; Macedo, Maria Luisa Bezerra de; Pontes, Maria Araci de Andrade; Sabadia, José Antonio BeltrãoINTRODUCTION: This study quantified Mycobacterium leprae bacilli in environmental water samples from five municipalities in the State of Ceará by quantitative polymerase chain reaction (qPCR) and compared the identified genotypes with those obtained from leprosy patient biopsies. METHODS: We collected five replicas from each of the 30 selected reservoirs and skin lesion biopsies from 25 new leprosy cases treate...
A clinical trial for uniform multidrug therapy for leprosy patients in Brazil :...
Penna, Gerson Oliveira; Pontes, Maria Araci de Andrade; Cruz, Rossilene Conceição da Silva; Gonçalves, Heitor de Sá; Penna, Maria Lúcia FernandesLeprosy will continue to be a public health problem for several decades. The World Health Organization (WHO) recommends that, for treatment purposes, leprosy cases be classified as either paucibacillary or multibacillary (MB). A uniform leprosy treatment regimen would simplify treatment and halve the treatment duration for MB patients. The clinical trial for uniform multidrug therapy (U-MDT) for leprosy patient...
Estudo clinico de multidrogaterapia uniforme para o tratamento da hanseníase no...
Pontes, Maria Araci de AndradeBackground: An open label randomized clinical trial to evaluate the effectiveness of an uniform six-months regimen to treat all leprosy patients (U-MDT/CT-BR) is being conducted in two national referral centers of the National Leprosy Control Program. Adding clofazimine to the current treatment for paucibacillary patients causes inquiry into possible increasing adverse effects to MDT. Objective: to describe the...
Prescrição e utilização da talidomida em área urbana no Nordeste do Brasil
Pontes, Maria Araci de AndradeIn result of new knowledge on its mechanism of action and pharmacological properties, thalidomide has been used for a number each bigger of professionals, for most diverse clinical conditions. Because of its high teratogenical potential, its safe and rational use requires an accompaniment for rigorous program of pharmacovigilance. The objective of this study was to evaluate the therapeutical prescription and th...