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Foxp3 induction in human and murine thymus precedes the CD4+ CD8+ stage but req...

Nunes-Cabaço, H.; C Ribot, Julie; Caramalho, Íris; Serra-Caetano, Ana; Silva-Santos, Bruno; E Sousa, Ana

The thymus generates a T-cell lineage dedicated to immune regulation, 'naturally occurring' regulatory T cells, best specified by the forkhead family transcription factor Foxp3. Here, we have conducted a parallel study in humans and mice where we have dissected the earliest stages of Foxp3 induction during thymocyte development. By analyzing a large collection of 21 human thymuses we show that Foxp3 can be cons...

Date: 2010   |   Origin: Repositório da Universidade de Lisboa
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