26 documents found, page 1 of 3
BRD9 status is a major contributor for cysteine metabolic remodeling through MS...
Hipólito, Ana; Xavier, Renato; Brito, Cheila; Tomás, Ana; Lemos, Isabel; Cabaço, Luís C.; Silva, Fernanda; Oliva, Abel; C. Barral, DuartePublisher Copyright: Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.; Cutaneous melanoma (CM) is the most aggressive skin cancer, showing globally increasing incidence. Hereditary CM accounts for a significant percentage (5-15 %) of all CM cases. However, most familial cases remain without a known genetic cause. Even though, BRD9 has been associated to CM as a susceptibility gene. ...
Membrane trafficking alterations in breast cancer progression
Ferreira, Andreia; Castanheira, Pedro; Escrevente, Cristina; C. Barral, Duarte; Barona, TeresaPublisher Copyright: Copyright © 2024 Ferreira, Castanheira, Escrevente, Barral and Barona.; Breast cancer (BC) is the most common type of cancer in women, and remains one of the major causes of death in women worldwide. It is now well established that alterations in membrane trafficking are implicated in BC progression. Indeed, membrane trafficking pathways regulate BC cell proliferation, migration, invasion, ...
Editorial
Huntosova, Veronika; Andreana, Marco; Mironov, Alexandre A.; C. Barral, Duarte
Melanin’s Journey from Melanocytes to Keratinocytes: Uncovering the Molecular M...
Bento-Lopes, Liliana; Cabaço, Luís C.; Charneca, João; Neto, Matilde V.; C Seabra, Miguel; C. Barral, DuarteFunding This research was funded by Fundação para a Ciência e a Tecnologia (Portugal) grant number PTDC/BIA-CEL/29765/2017 and Ph.D. fellowships to L.B.-L., L.C.C., M.V.N. and J.C. (numbers SFRH/BD/131938/2017, 2020.08812.BD, PD/BD/137442/2018, and PD/BD/136905/2018, respectively). This work was also supported by iNOVA4Health—UIDB/04462/2020 and UIDP/04462/2020—and by the Associated Laboratory LS4FUTURE (LA/P/0...
Reconstructed human pigmented skin/epidermis models achieve epidermal pigmentat...
Hall, Michael J; Lopes-Ventura, Sara; Neto, Matilde V; Charneca, João; Zoio, Patricia; C Seabra, Miguel; Oliva, Abel; C. Barral, DuarteFunding: We thank the Electron Microscopy Facility at the Instituto Gulbenkian de Ciência, the Pathological Anatomy service in the Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG) and the Histology Facility at CEDOC for technical assistance. This project was supported by Fundação para a Ciência e a Tecnologia (FCT), Portugal through FCT Unit iNOVA4Health – UIDB/04462/2020 and UIDP/04462/2020...
The Dark Side of Melanin Secretion in Cutaneous Melanoma Aggressiveness
Cabaço, Luís C.; Tomás, Ana; Pojo, Marta; C. Barral, DuarteFunding Information: LC is funded by an FCT PhD fellowship (2020.08812.BD). AT is funded by an FCT PhD fellowship (2021.06204.BD). MP is funded by Liga Portuguesa Contra o Cancro – Núcleo Regional do Sul (LPCC-NRS). DB lab is supported by Fundação para a Ciência e a Tecnologia (FCT) through grant PTDC/BIA-CEL/29765/2017. This publication was funded by the iNOVA4Health - UIDB/04462/2020 and UIDP/04462/2020, a pr...
Melanocore uptake by keratinocytes occurs through phagocytosis and involves Pro...
Moreiras, Hugo; Bento-Lopes, Liliana; Neto, Matilde V; Escrevente, Cristina; Cabaço, Luís C.; Hall, Michael J; Ramalho, José S; C Seabra, MiguelFunding: The authors would like to thank the scientific and technical assistance from the CEDOC Cell Culture, Flow Cytometry and Microscopy facilities. We also thank the Electron Microscopy Facility of Instituto Gulbenkian de Ciência for technical assistance. The authors also thank Dorothy Bennett and Elena Sviderskaya (St. George's University of London, UK), Susana Lopes (CEDOC, NOVA Medical School) and Paulo ...
Liposomal Formulations of a New Zinc(II) Complex Exhibiting High Therapeutic Po...
Ribeiro, Nádia; Albino, Melissa; Ferreira, Andreia; Escrevente, Cristina; C. Barral, Duarte; Pessoa, João Costa; Reis, Catarina PintoFunding: The authors thank the financial support from Fundação para a Ciência e Tecnologia (FCT) through projects UIDB/00100/2020, UIDP/00100/2020, UIDB/04138/2020, UIDP/04138/2020, LA/P/0056/2020, and PTDC/QUI-QIN/0586/2020. N. Ribeiro acknowledges FCT for the SFRH/BD/ 135797/2018 grant. Andreia Ferreira acknowledges FCT for the PD/BD/135506/2018 grant.; Colorectal cancer is the second leading cause of cancer-...
RAB3A Regulates Melanin Exocytosis and Transfer Induced by Keratinocyte-Conditi...
Cabaço, Luís C.; Bento-lopes, Liliana; Neto, Matilde V.; Ferreira, Andreia; Staubli, Wanja B.l.; Ramalho, José S.; C Seabra, Miguel; C. Barral, DuarteFunding: We would like to thank our group for the critical reading of the manuscript and the NMS microscopy and cell culture facilities, as well as José Belo’s group, for the kind gift of mouse embryonic fibroblasts. This study was supported by Fundação para a Ciência e a Tecnologia (Portugal) through grant PTDC/BIA-CEL/29765/2017 and PhD fellowships to LCC, MVN, LBL and AF (2020.08812.BD, PD/BD/137442/2018, SF...
Development of Dl1.72, a novel anti-DLL1 antibody with anti-tumor efficacy agai...
Silva, Gabriela; Sales-Dias, Joana; Casal, Diogo B.; Alves, Sara; Domenici, Giacomo; Barreto, Clara; Matos, Carolina; Lemos, Ana R.; Matias, Ana T.Funding Information: Funding: This research was funded by Fundação para a Ciência e Tecnologia, Portugal, grants PTDC/BBB-BMD/4497/2014 (to A.B.) and PD/BD/113987/2015 (to J.S.-D.), iBETXplore grants 3D-ABC-PI-717 (to G.D.) and BiACaT-HER2:JAG1 (to G.S.). iNOVA4Health—UIDB/04462/2020 and UIDP/04462/2020, a program financially supported by Fundação para a Ciência e Tecnolo-gia/Ministério da Ciência, Tecnologia e...