4 documents found, page 1 of 1
Engineering patient-on-a-chip models for personalized cancer medicine
Caballero, D.; Reis, R. L.; Kundu, Subhas CTraditional in vitro and in vivo models typically used in cancer research have demonstrated a low predictive power for human response. This leads to high attrition rates of new drugs in clinical trials, which threaten cancer patient prognosis. Tremendous efforts have been directed towards the development of a new generation of highly predictable preclinical models capable to reproduce in vitro the biological co...
Preface
Caballero, D.; Kundu, Subhas C; Reis, R. L.The cellular microenvironment has a fundamental regulatory role in major cellular functions. This microenvironment is made of an array of polymeric proteins and glycoproteins that constitute the extracellular matrix (ECM). The ECM does not serve only as a structural support but also as a bioactive material. This influences a large plethora of cellular (physiological and pathological) processes, such as differen...
Cell-derived matrices - Part B
Caballero, D.; Kundu, Subhas C; Reis, R. L.The cellular microenvironment has a fundamental regulatory role in major cellular functions. This microenvironment is made of an array of polymeric proteins and glycoproteins that constitute the extracellular matrix (ECM). The ECM does not serve only as a structural support but also as a bioactive material. This influences a large plethora of cellular (physiological and pathological) processes, such as differen...
Late differentiation syndrome in acute promyelocytic leukemia: a challenging di...
Cabral, R.; Caballero, J.; Alonso, S.; Dávila, J.; Cabrero, M.; Caballero, D.; Vázquez, L.; Sánchez-Guijo, F.; López, L.; Cañizo, M.; Mateos, M.Detailed knowledge about differentiation syndrome (DS) has remained limited. There are 2 large studies conducted by the Spanish workgroup PETHEMA (Programa Español de Tratamientos en Hematología; Spanish Program on Hematology Treatments) and the European group trial (LPA 96-99 and APL 93) in which the incidence, characteristics, prognostic factors and outcome of patients developing DS are evaluated. Both have d...