Alpha-synuclein (aSyn) is a central player in the pathogenesis of synucleinopathies due to its accumulation in typical protein aggregates in the brain. However, it is still unclear how it contributes to neurodegeneration. Type-2 diabetes mellitus is a risk factor for Parkinson's disease (PD). Interestingly, a common molecular alteration among these disorders is the age-associated increase in protein glycation. ...
Tetrazole/tetrazolate monocydopentadienyliron(II) and ruthenium(II) compounds of general formulas [(eta(5)-C5H5)M(dppe)(N-4(H)CC6H4NO2)][PF6]/[(eta(5)-C5H5)M(dppe)(N4CC6H4NO2] were investigated for their pH-switching second-order nonlinear optical (SONLO) properties. Compounds [(eta(5)-C5H5)M(dppe)(N4CC6H4NO2) (M = Fe, Ru) and compound [(eta(5)-C5H5)Ru(dppe)(N-4(H)CC6H4NO2)][PF6] were fully characterized by (H-...
No presente trabalho é descrita a síntese e caracterização de uma série de novos compostos iónicos do tipo η5-monociclopentadienilo de ruténio(II) e ferro(II), com ligandos coordenados derivados dos compostos 1,2-di-(2-tienil)-eteno, benzo[1,2-b;4,3- b']ditiofeno e tetratia-[7]-heliceno, com vista à obtenção de efeitos significativos de Óptica Não Linear (NLO). Com o mesmo propósito, foram também sintetizados n...