9 documents found, page 1 of 1
Reduced graphene oxide–reinforced tricalcium phosphate/gelatin/chitosan light-r...
Cabral, Cátia S. D.; Melo-Diogo, Duarte de; Ferreira, Paula; Moreira, André F.; Correia, I.J.Bone is a mineralized tissue with the intrinsic capacity for constant remodeling. Rapid prototyping techniques, using biomaterials that mimic the bone native matrix, have been used to develop osteoinductive and osteogenic personalized 3D structures, which can be further combined with drug delivery and phototherapy. Herein, a Fab@Home 3D Plotter printer was used to promote the layer-by-layer deposition of a comp...
Lignin-enriched tricalcium phosphate/sodium alginate 3D scaffolds for applicati...
Barroso, A.S. Silva; Cabral, Cátia S. D.; Ferreira, Paula; Moreira, André F.; Correia, I.J.The bone is a connective, vascularized, and mineralized tissue that confers protection to organs, and participates in the support and locomotion of the human body, maintenance of homeostasis, as well as in hematopoiesis. However, throughout the lifetime, bone defects may arise due to traumas (mechanical fractures), diseases, and/or aging, which when too extensive compromise the ability of the bone to self-regen...
Chitin- and chitosan-based strategies in wound healing
Cabral, Cátia S. D.; Graça, Mariana F. P.; Moreira, André F.; Diogo, Duarte de Melo; Correia, I.J.Nowadays, chronic wounds are still a huge health problem with a high impact on the patients’ quality of life. In this way, the development of an ideal wound dressing is of utmost importance. To accomplish that, researchers have been using natural polymers to produce new types of dressings, that can activate/direct specific cellular responses, leading to an improved healing process. Among the natural polymers, c...
In Vivo bone tissue induction by freeze-dried collagen-nanohydroxyapatite matri...
Wang, Pinpin; Perche, Federico; Midoux, Patrick; Cabral, Cátia S. D.; Malard, Virginie; Correia, I.J.; EI-Hafci, Hanane; Petite, HervéMessenger RNA (mRNA) activated matrices (RAMs) are interesting to orchestrate tissue and organ regeneration due to the in-situ and sustained production of functional proteins. However, the immunogenicity of in vitro transcribed mRNA and the paucity of proper in vivo mRNA delivery vector need to be overcome to exert the therapeutic potential of RAM. We developed a dual mRNAs system for in vitro osteogenesis by c...
Injectable in situ forming thermo-responsive graphene based hydrogels for cance...
Sousa, Rita Lima; Diogo, Duarte de Melo; Alves, Cátia; Cabral, Cátia S. D.; Miguel, Sónia P.; Mendonça, António; Correia, I.J.Functionalized graphene oxide (GO) and reduced GO (rGO) based nanomaterials hold a great potential for cancer photothermal therapy. However, their systemic administration has been associated with an accelerated blood clearance and/or with suboptimal tumor uptake. To address these limitations, the local delivery of GO/rGO to the tumor site by 3D matrices arises as a promising strategy. In this work, injectable c...
Hyaluronic acid - Based wound dressings: A review
Graça, Mariana F. P.; Miguel, Sónia P.; Cabral, Cátia S. D.; Correia, I.J.Hyaluronic acid (HA), a non-sulfated glycosaminoglycan (GAG), is a major component of skin extracellular matrix (ECM) and it is involved in the inflammatory response, angiogenesis, and tissue regeneration process. Due to the intrinsic properties of HA (such as biocompatibility, biodegradability and hydrophilic character), it has been used to produce different wound dressings, namely sponges, films, hydrogels, a...
Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug del...
Sequeira, Rosa Maria Saraiva; Miguel, Sónia; Cabral, Cátia S. D.; Moreira, André; Ferreira, Paula; Correia, I.J.Nanofiber-based wound dressings are currently being explored as delivery systems of different biomolecules for avoiding skin infections as well as improve/accelerate the healing process. In the present work, a nanofibrous membrane composed of poly(vinyl alcohol) (PVA) and lysine (Lys) was produced by using the electrospinning technique. Further, anti-inflammatory (ibuprofen (IBP)) and antibacterial (lavender oi...
Production and characterization of a novel asymmetric 3D printed construct aime...
Miguel, Sónia; Cabral, Cátia S. D.; Moreira, André; Correia, I.J.Skin is a complex organ that act as the first protective barrier against any external threat. After an injury occurs, its structure and functions must be re-established as soon as possible. Among different available skin substitutes (epidermal, dermal and dermo-epidermal), none of them is fully capable of reproducing/re-establishing all the features and functions of native skin. Herein, a three-dimensional skin...
Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing
Alves, Patrícia; Santos, Marta; Mendes, Sabrina; Miguel, Sónia P.; Sá, Kevin D. de; Cabral, Cátia S. D.; Correia, Ilídio J.; Ferreira, PaulaRecently, the biomedical scientists who are working in the skin regeneration area have proposed asymmetric membranes as ideal wound dressings, since they are able to reproduce both layers of skin and improve the healing process as well as make it less painful. Herein, an electrospinning technique was used to produce new asymmetric membranes. The protective layer was composed of a blending solution between polyc...