2 documents found, page 1 of 1
Potent antileukemic action of naphthoquinoidal compounds : evidence for an intr...
Cavalcanti, Bruno C.; Cabral, Igor O.; Rodrigues, Felipe A. R.; Barros, Francisco W. A.; Rocha, Danilo D.; Magalhães, Hemerson I. F.; Moura, Dinara J.The current study describes that nor-β-lapachone and its arylamino derivatives, iodinated and methylated naphthoquinones and nor-β-lapachone-based 1,2,3-triazoles exhibited pronounced cytotoxic effects against four human leukemia cell lines (HL-60, K562, Molt-4 and Jurkat). Nor-β- lapachones arylamino substituted with potent activity were identified, revealing themselves as potential prototypes against tumor ce...
Genetic toxicology evaluation of essential oil of Alpinia zerumbet and its chem...
Cavalcanti, Bruno C.; Ferreira, José R. O.; Cabral, Igor O.; Magalhães, Hemerson I. F.; Oliveira, Cecília C. de; Rodrigues, Felipe A. R.Essential oil (EO) of Alpinia zerumbet leaves, at non-toxic concentrations (50–300 l g/mL), did not induce genotoxicity in human leukocytes. However, at the highest concentration (500 l g/mL) tested caused a reduction in cell proliferation and viability, and an increase in DNA damage. Moreover, in vivo experi- ments showed that EO (400 mg/kg) did not exert mutagenicity on peripheral blood cells and bone mar- ro...