18 documents found, page 1 of 2
A novel patient-derived cutaneous melanoma cell line reveals key features of me...
Tomás, Ana; Roque, Lúcia; Francisco, Inês; Silva, Ana Luísa; Nunes, Hugo; Gouveia, Emanuel; Carvalho, Elisabete; Farricha, Victor; Moura, CecíliaPublisher Copyright: Copyright © 2025 Tomás, Roque, Francisco, Silva, Nunes, Gouveia, Carvalho, Farricha, Moura, Rosa, Garrido, Albuquerque, Pereira, Cabral and Pojo.; Introduction: Cutaneous melanoma (CM) is an aggressive form of skin cancer, with rising incidence and poor prognosis at advanced stages. While early-stage CM typically carries a favorable prognosis, a small subset of patients relapses and progres...
Improvement of Mineral and Bone Disorders After Renal Transplantation
Ferreira, Ana Carina; Mendes, Marco; Silva, Cecília; Cotovio, Patrícia; Aires, Inês; Navarro, David; Caeiro, Fernando; Ramos, Rúben; Salvador, RuteCopyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.; BACKGROUND: Posttransplant mineral and bone diseases are causes of fractures, and their association with cardiovascular events is being studied. METHODS: We analyzed the evolution of biochemical, histological, and imaging parameters pre- and 1 y post-renal transplantation in 69 patients and correlated mineral and bone findings with coronary calc...
Expression of HLA-DR in Cytotoxic T Lymphocytes: A Validated Predictive Biomark...
Saraiva, DP; Azeredo-Lopes, S; Antunes, A; Salvador, R; Borralho, P; Assis, B; Pereira, IL; Seabra, Z; Negreiros, I; Jacinto, A; Braga, S; Cabral, MGNeoadjuvant chemotherapy (NACT) is common in breast cancer (BC) treatment, though more than half of the patients lack an effective response. Therefore, new predictive biomarkers and alternative therapies are crucial. Previously, we proposed HLA-DR-expressing cytotoxic T lymphocytes (CTLs) as a potential biomarker of the response to NACT. To validate this observation and further investigate these cells, 202 BC p...
Development of Dl1.72, a Novel Anti-DLL1 Antibody with Anti-Tumor Efficacy agai...
Silva, G; Sales-Dias, J; Casal, D; Alves, S; Domenici, G; Barreto, C; Matos, C; Lemos, AR; Matias, AT; Kucheryava, K; Ferreira, A; Moita, MR; Braga, SAberrant Notch signaling is implicated in several cancers, including breast cancer. However, the mechanistic details of the specific receptors and function of ligand-mediated Notch signaling that promote breast cancer remains elusive. In our studies we show that DLL1, a Notch signaling ligand, is significantly overexpressed in ERα+ luminal breast cancer. Intriguingly, DLL1 overexpression correlates with poor pr...
Circulating low density neutrophils of breast cancer patients are associated wi...
Saraiva, Diana P; Correia, Bruna F; Salvador, Rute; de Sousa, Nídia; Jacinto, Antonio; Braga, Sofia; Cabral, MGFunding: This work was supported by Liga Portuguesa Contra o Cancro; Fundação para a Ciência e Tecnologia (PD/BD/114023/2015, SFRH/BD/148422/2019 and 2021.08031.BD); and iNOVA4Health (UIDB/04462/2020 and DAI/2019/46).; Neutrophils are prominent immune components of tumors, having either anti-tumor (N1) or pro-tumor activity (N2). Circulating neutrophils, divided into high density neutrophils (HDN) and low densi...
Development of Dl1.72, a novel anti-DLL1 antibody with anti-tumor efficacy agai...
Silva, Gabriela; Sales-Dias, Joana; Casal, Diogo B.; Alves, Sara; Domenici, Giacomo; Barreto, Clara; Matos, Carolina; Lemos, Ana R.; Matias, Ana T.Funding Information: Funding: This research was funded by Fundação para a Ciência e Tecnologia, Portugal, grants PTDC/BBB-BMD/4497/2014 (to A.B.) and PD/BD/113987/2015 (to J.S.-D.), iBETXplore grants 3D-ABC-PI-717 (to G.D.) and BiACaT-HER2:JAG1 (to G.S.). iNOVA4Health—UIDB/04462/2020 and UIDP/04462/2020, a program financially supported by Fundação para a Ciência e Tecnolo-gia/Ministério da Ciência, Tecnologia e...
Expression of hla-dr in cytotoxic t lymphocytes
Saraiva, Diana P.; Azeredo-Lopes, Sofia; Antunes, Ana; Salvador, Rute; Borralho, Paula; Assis, Beatriz; Pereira, Isabel L.; Seabra, Zita; Negreiros, IdaFunding Information: Funding: This work was supported by Terry Fox Research Grant 2019 from Liga Portuguesa Contra o Cancro; Clinical Research Prize 2018 from Consortium Tagus Tank; Fundação para a Ciência e Tecnologia (PD/BD/114023/2015 for DPS and SFRH/BD/148422/2019 for RS) and iNOVA4Health (UIDB/04462/2020, DAI/2019/46). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.; Neoadju...
Development of Dl1.72, a Novel Anti-DLL1 Antibody with Anti-Tumor Efficacy agai...
Silva, G; Sales-Dias, J; Casal, D; Alves, S; Domenici, G; Barreto, C; Matos, C; Lemos, A; Matias, A; Kucheryava, K; Ferreira, A; Moita, MR; Braga, SThe Notch-signaling ligand DLL1 has emerged as an important player and promising therapeutic target in breast cancer (BC). DLL1-induced Notch activation promotes tumor cell proliferation, survival, migration, angiogenesis and BC stem cell maintenance. In BC, DLL1 overexpression is associated with poor prognosis, particularly in estrogen receptor-positive (ER+) subtypes. Directed therapy in early and advanced BC...
Establishment of a 3D Co-culture With MDA-MB-231 Breast Cancer Cell Line and Pa...
Saraiva, Diana P.; Matias, Ana T.; Braga, Sofia; Jacinto, Antonio; Cabral, MGFunding: This work was supported by Tagus Tank Consortium Projects in Medicine Award; Terry Fox 2019 Research Grant from Liga Portuguesa Contra o Cancro; Fundação para a Ciência e Tecnologia (PD/BD/114023/2015 and PD/BD/114053/2015) and iNOVA4Health (UIDB/04462/2020 and DAI/2019/46).; 3D cell culture including different cell types, such as immune cells, is a representative platform that mimics the tumor microen...
Evaluating SARS-CoV-2 Seroconversion Following Relieve of Confinement Measures
Gonçalves, Juliana; Sousa, Rita L.; Jacinto, Maria J.; Silva, Daniela A.; Paula, Filipe; Sousa, RD; Zahedi, Sara; Carvalho, Joana; Cabral, MGFunding: This work was supported by FCT grants (PTDC/MECREU/29520/2017 to HS and CHRC UIDB/4923/2020, UIPD/4923/2020). JG, MJJ, and DAS are supported by FCT through /BD/128343/2017, PTDC/EGE-OGE/32573/2017, and PD/BD/137409/2018, respectively. The anti-SARSCoV-2 ELISA assay was developed within the context of Serology4COVID consortium, in which IBET (Instituto de Biologia Experimental e Tecnológica) produced an...