2 documents found, page 1 of 1
Metabolism-Targeted Therapy in NSCLC - A New Theranostics Inhalation Approach U...
Mendes, Cindy; Martins, Filipa; Granja, Sara; Gonçalves, Joana; Barros, Hélio; Casimiro, Teresa; Aguiar-Ricardo, Ana; Silva, Fernanda; Abreu, BrunaLung cancer is one of the most lethal cancers globally, primarily due to delayed diagnosis and lack of specific and effective therapy. Increased lactate production and consumption, along with cysteine metabolic reliance, are features identified in NSCLC in our recent studies. Cancer metabolic remodeling leads to excessive ROS production, triggering oxidative stress, promoting angiogenesis, causing cellular and ...
Release profile of ibuprofen in β-cyclodextrin complexes from two different sol...
Salústio, Paulo; Feio, Gabriel; Figueirinhas, João; Cabral-Marques, Helena; Costa, Paulo; Pinto, JoãoThe objective of this work was to develop solid dosage forms using powders containing inclusion complexes (ibuprofen with β-cyclodextrin) which were used to produce tablets (direct compression without additional excipients) and pellets (extrusion/spheronization) from wet mass containing 40% (w/w) of microcrystalline cellulose. The pellets also demonstrated that during preparation of the wet mass, the inclusion ...