8 documents found, page 1 of 1
Evaluation of bone turnover markers and serum minerals variations for predictin...
Sousa, Cristina P.; Lopez-Peña, Mónica; Guzon, Fernando M.; Abreu, Humberto V. de; Luís, Maurino R.; Viegas, Carlos A.; Camassa, José A.Bone turnover markers (BTMs) have been considered as an auxiliary method of following the fracture healing process and for early prediction of impaired bone healing. A better understanding of the potential of BTMs in this application could allow for earlier interventions and improved patient care. The aim of this study with a large animal experimental model was to assess the variation of bone formation markers ...
Haematological and biochemical parameters in Churra-da-Terra-Quente ewes from t...
Dias, I. R.; Viegas, C. A.; Silva, A. M.; Pereira, H. F.; Sousa, C. P.; Carvalho, P. P.; Cabrita, A. S.; Fontes, P. J.; Silva, S. R.; Azevedo, J. M.T.Hematological and biochemical parameters, including plasma electrolytes and thyroid hormones, were determined in 73 clinically healthy Churra-da-Terra-Quente ewes, a typical breed from the northeast of Portugal. The hemogram values were: erythrocytes 9.8±1.51012/L; haemoglobin 118.1±19.1g/L; haematocrit 40.8±5.9%; leukocytes 5.7±1.8109/L; and platelets 544.3±177.2109/L. The thrombin time was 17.3±1.7 seconds...
Expressão imunoistoquímica da proteína S-100 na discondroplasia da tíbia
Capela e Silva, F.; Lamy, E.; Reis, J. C.; Potes, J. C.; Pereira, A.; Cabrita, A. S.It was compared, by immunohistochemistry, the expression of S-100 protein from normal and tibial dyschondroplasia (TD) growth plates. The results suggest that S-100 may be involved in growth plate homeostasis. The expression of S-100 in dyschondroplastic chondrocytes may be due to a low level of calcium in the lesion and/or compression of chondrocytes by the accumulated matrix. One further possibility is the as...
Expressão da caderina na discondroplasia tibial
Capela e Silva, F.; Lamy, E.; Pereira, A.; Reis, J. C.; Potes, J.C.; Cabrita, A. S.By immunohistochemistry the expression of a pan-cadherin antibody that recognizes a wide variety of cadherins in chondrocytes from normal and tibial dyschondroplasia (TD) growth plates was compared. Surprisingly, an upregulated expression that was not expected in TD lesion chondrocytes was observed. The reason for this apparent upregulation is not clear. The increased expression may simply be due to the particu...
Haematological and biochemical parameters in Churra-da-Terra-Quente ewes from t...
Dias, Isabel R.; Viegas, Carlos A.; Silva, A. M.; Pereira, H. F.; Sousa, C. P.; Carvalho, P. P.; Cabrita, A. S.; Fontes, P. J.; Silva, S. R.Hematological and biochemical parameters, including plasma electrolytes and thyroid hormones, were determined in 73 clinically healthy Churra-da-Terra-Quente ewes, a typical breed from the northeast of Portugal. The hemogram values were: erythrocytes 9.8±1.51012/L; haemoglobin 118.1±19.1g/L; haematocrit 40.8±5.9%; leukocytes 5.7±1.8109/L; and platelets 544.3±177.2109/L. The thrombin time was 17.3±1.7 seconds...
Haematology, genotoxicity, enzymatic activity and histopathology as biomarkers ...
Sánchez-Chardi, A.; Marques, C. C.; Gabriel, S. I.; Capela-Silva, F.; Cabrita, A. S.; López-Fuster, M. J.; Nadal, J.; Mathias, M. L.Haematological (WBC, RBC, Hgb and Hct) and genotoxicity (MNT) parameters, hepatic enzymatic activities (GST, GPx and GR), and a histopathological evaluation of liver, kidneys and gonads were assessed as general biomarkers of metal pollution in the shrew Crocidura russula inhabiting a pyrite mining area. Specimens exposed to metals presented a few significant alterations when compared with reference animals: GST...
Assessment of bone formation markers under controlled environmental conditions ...
Dias, Isabel R.; Viegas, Carlos A.; Azevedo, Jorge T.; Costa, E. M.; Lourenço, P.; Rodrigues, A.; Cabrita, A. S.Eighteen healthy skeletally mature (3 years old) ewes, with an average weight of 45 kg, of the Portuguese Churra da Terra Quente breed were used to evaluate the normal values of total and bone-specific isoform of alkaline phosphatase serum activities (ALP and BALP, respectively) and serum osteocalcin (OC) and their correlation with the serum minerals – calcium (Ca), phosphorus (P), magnesium (Mg) and ionized ca...
Evaluation of the antitumoral effect mediated by IL-12 and HSV-tk genes when de...
Faneca, H.; Cabrita, A. S.; Simões, S.; Lima, M. C. Pedroso deIn the present work, we used a novel albumin-associated lipoplex formulation, containing the cationic lipid 1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (EPOPC) and cholesterol (Chol), to evaluate the antitumoral efficacy of two gene therapy strategies: immuno-gene therapy, mediated by IL-12 gene expression, and "suicide" gene therapy, mediated by HSV-tk gene expression followed by ganciclovir (GCV) tr...