5 documents found, page 1 of 1
Improving discrimination in the grading of rat mammary tumors using two-dimensi...
Lopes, Ana C.; Cova, Tânia F. G. G.; Pais, Alberto A. C. C.; Pereira, Jorge L. G. F. S. C.; Colaço, Bruno; Cabrita, António M. S.This work aims at characterizing rat mammary tumors induced by 7,12-dimethylbenz(a)anthracene (DMBA) and the respective malignancy potential, commonly graded with histopathology features grouped by intensity levels. Tumors were described over fourteen multiple ranged microscopic parameters and a comprehensive characterization of the histological patterns and their relation with tumor grade was carried out by pr...
Toxicological in vivo studies of an oral insulin nanosystem
Reis, Catarina Pinto; Veiga, Francisco; Nunes, Patrícia; Soares, Ana Francisca; Laranjeira, Tânia; Carvalho, Rui; Jones, John; Figueiredo, Isabel V.http://www.sciencedirect.com/science/article/B6TCR-4PKH640-7G/1/31df064ec957f50aa568d739cd5d7419
Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels
Ferreira, Lino; Gil, Maria H.; Cabrita, António M. S.; Dordick, Jonathan S.We have prepared unique macroporous and ordered dextran-based hydrogels using a single-step biocatalytic transesterification reaction between dextran and divinyladipate in neat dimethylsulfoxide. These hydrogels show a unimodal distribution of interconnected pores with average diameters from 0.4 to 2.0 [mu]m depending on the degree of substitution. In addition, the hydrogels show a higher elastic modulus for a ...
Biocompatibility of chemoenzymatically derived dextran-acrylate hydrogels
Ferreira, Lino; Rafael, Ana; Lamghari, Meriem; Barbosa, Mario A.; Gil, Maria H.; Cabrita, António M. S.; Dordick, Jonathan S.The biocompatibility of chemoenzymatically generated dextran-acrylate hydrogels has been evaluated in vitro, using human foreskin fibroblasts, and in vivo, by subcutaneous and intramuscular implantation in Wistar rats for up to 40 days. In vitro tests show that hydrogel extracts only minimally reduced (<10%) the mitochondrial metabolic activity of fibroblasts. Direct contact of the hydrogels with cells induced ...
Techniques of intestinal transplantation in rat
Lopes, Maria Francelina S. C.; Cartucho, Daniel J. F.; Cabrita, António M. S.; Patrício, João A. B.Two surgical models of intestinal transplantation in the rat are described. One is the implantation of fetal and newborn intestine as free grafts into the omentum of adult recipients, the other the adult intestine transplantation as an accessory graft using vascular anastomoses. A hundred and sixteen small-bowel transplantations were done; 36 of which were fetal intestine (group I), 40 of newborn intestine (gro...