25 documents found, page 1 of 3
Proteinase 3 (PR3)-Antineutrophil Cytoplasmic Antibody in a Patient with Minima...
Freitas,Joana; Sala,Inês; Oliveira,João; Campos,Andreia; Santos,Sofia; Santos,Josefina; Cabrita,AntónioABSTRACT Antineutrophil cytoplasmic antibodies (ANCA) are useful as markers for systemic vasculitis. PR3-ANCA antibodies have been also identified in association with chronic inflammatory and infectious conditions, other autoimmune diseases, malignancy, and certain drugs. The association of PR3 and minimal change disease (MCD) without vasculitis is not an expected finding. We report a case of MCD with PR3-ANCA ...
Association between severe chronic kidney disease defined by cystatin-c and cre...
Tavares,Joana; Santos,Josefina; Silva,Filipa; Oliveira,João; Malheiro,Jorge; Campos,Andreia; Cabrita,AntónioABSTRACT Introduction: Estimated glomerular filtration rate (eGFR) based on serum cystatin-C (sCys) seems as accurate as when based on serum creatinine (sCr), but sCys seems a better predictor of adverse outcomes. We aimed to study whether sCys could be a reliable tool for the prediction of adverse outcomes in elderly patients with severe chronic kidney disease (CKD). Methods: A group of 348 elderly patients wi...
Acute hyperammonemic encephalopathy - an indication for an extracorporeal depur...
Silva,Filipa; Tavares,Joana; Castro,Ana; Guimas,Arlindo; Freitas,Cristina; Pimentel,João Pedro; Cabrita,AntónioABSTRACT Introduction: Ammonia is a resultant molecule from the protein metabolism that can be neurotoxic when present in high concentrations, causing brain edema and encephalopathy. Extracorporeal blood purification technique (EBPT) can play a role in reducing both ammonia and urea blood levels. However, there are no specific guidelines for its use in hyperammonemia, due to its low incidence and scarce literat...
Peritoneal access - a pressing problem
Valério,Patrícia; Carvalho,Maria João; Santos,Olívia; Cabrita,António; Rodrigues,AnabelaABSTRACT In Portugal, as well as in Europe, peritoneal dialysis (PD) use remains low. Reorganization of PD units including a well‑structured peritoneal access management protocol are fundamental to improve the take‑up of this therapy. We analyzed the procedure and outcomes in a PD unit, addressing two key quality questions: at which level of estimated glomerular filtration rate (eGFR) were patients referred to ...
Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyon...
Moreira,Carla Leal; Cunha,Liliana; Correia,Sofia; Silva,Filipa; Castro,Ana; Tavares,Joana; Carvalho,Maria João; Oliveira,José Carlos; Santos,OlíviaABSTRACT Introduction: It has been suggested that cystatin C levels are modified by obesity and inflammation. Furthermore, cystatin C has been associated with cardiovascular events and mortality outcomes. Aim: To study the association of cystatin C with the metabolic profile and cardiovascular disease of peritoneal dialysis patients. Methods: Data collected included clinical, laboratorial, and multifrequency bi...
ABO-incompatible living donor kidney transplantation in Portugal
Ribeiro,Catarina Isabel; Silva,Natália; Malheiro,Jorge; Almeida,Manuela; Pedroso,Sofia; La Salete Martins,Maria; Dias,Leonídio; Henriques,António CastroIntroduction: ABO incompatibility was considered a barrier to kidney transplant. However, the shortage of available organs for transplantation and the excellent long-term results further establish ABO-incompatible (ABOi) as a safe and effective therapeutic strategy. The aim of the present study was to evaluate the outcomes of ABOi transplantation in terms of graft survival and function, rejection episodes and i...
Urgent-Start Peritoneal Dialysis - a viable option?: A case report and literatu...
Tavares,Joana; Silva,Filipa; Lima,Anna; Carvalho,Maria João; Cabrita,António; Rodrigues,AnabelaBackground: Many patients with end-stage renal disease start renal replacement therapy in an unplanned manner. The vast majority initiate hemodialysis by a central venous catheter, since its use is more widespread and available. This technique is associated with a high risk of infection and damage of the vascular patrimony associated with the use of central veins. Urgent-start peritoneal dialysis comes as an al...
Validation of a model to predict six-month mortality in incident elderly dialys...
Santos,Josefina; Oliveira,Pedro; Malheiro,Jorge; Campos,Andreia; Correia,Sofia; Cabrita,António; Lobato,Luísa; Fonseca,IsabelBackground and objectives: To evaluate RRT benefits and risks and to inform patients and their families about ESRD treatment options, we have developed a prognostic score to predict 6-month mortality in elderly ESRD patients initiating dialysis. Five independent predictors were identified and a point system was constructed: age 75 years or older (2 points), coronary artery disease (2 points), cerebrovascular di...
SARS-CoV-2 infection in hemodialysis patients: Preliminary data from a Portugue...
Tavares,Joana; Dias,Bruno Fraga; Oliveira,João Pedro; Sala,Inês; Silva,Filipa; Castro,Ana; Freitas,Cristina; Fonseca,Tomás; Pimentel,João PedroBackground: In December 2019, a new form of coronavirus was identified (COVID-19) and quickly became a worldwide pandemic. Previous data reported a more severe disease in older patients, with high comorbidities, which are common features in hemodialysis patients. Scarce data is available about the clinical presentation and outcomes in this population. For this reason, we aim to report the characteristics of COV...
Rituximab-induced hypersensitivity pneumonitis in a kidney transplant patient
Silva,Natália; Ribeiro,Catarina Isabel; Almeida,Manuela; Malheiro,Jorge; Pedroso,Sofia; Martins,Maria La Salete; Dias,Leonídio; Henriques,António CastroRituximab (RTX) is a chimeric anti-CD20 monoclonal antibody that has been associated with delayed pulmonary toxicity. In patients receiving RTX, hypersensitivity pneumonitis, although rare, should be considered in the appropriate clinical and radiographic setting. The authors present a case of hypersensitivity pneumonitis associated with a single dose of RTX treatment in a kidney transplanted patient with acute...