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N-1,2,3-Triazole-Isatin Derivatives: Anti-proliferation effects and target iden...
Busto, N.; Leitão-Castro, J.; García-Sosa, A.T.; Cadete, F.; Marques, C.S.; Freitas, R.; Burke, A.J.Molecular hybridization approaches have become an important strategy in medicinal chemistry, and to this end, we have developed a series of novel N-1,2,3-triazole–isatin hybrids that are promising as tumour anti-proliferative agents. Our isatin hybrids presented high cytotoxic activity against colon cancer cell line SW480, lung adenocarcinoma cell line A549, as well as breast cancer cell lines MCF7 and MDA-MB-2...
Date: 2023
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Origin: Repositório Científico da Universidade de Évora