4 documents found, page 1 of 1
Antiretroviral drugs saquinavir and ritonavir reduce inhibitory concentration v...
Brilhante, Raimunda Sâmia Nogueira; Caetano, Érica Pacheco; Riello, Giovanna Barbosa Riello; Guedes, Glaucia Morgana de MeloRecent studies have shown that some drugs that are not routinely used to treat fungalinfections have antifungal activity, such as protease inhibitor antiretroviral drugs. This studyinvestigated the in vitro susceptibility of Histoplasma capsulatum var. capsulatum to saquinavirand ritonavir, and its combination with the antifungal itraconazole. The susceptibility assaywas performed according to Clinical and Labo...
Easy storage strategies for sporothrix spp. strains
Brilhante, Raimunda Sâmia Nogueira; Silva, Natalya Fechine; Lima, Rita Amanda Chaves de; Caetano, Érica Pacheco; Alencar, Lucas Pereira deThe present study evaluated the maintenance of Sporothrix spp. (6 Sporothrix brasiliensis;6S. schenckii;5 S. mexicana, and 3 S. globosa) in saline at 4 C, and in 10% glycerol plus either 10% lactose or 10% sucrose, at -20 C and -80 C. Viability was assessed after 3, 6, and 9 months of storage, through the recovery of strains on potato dextrose agar and analysis of macro- and micromorphological features. Conidiu...
Synergistic Effect of Antituberculosis Histoplasma capsulatum var. capsulatum D...
Caetano, Érica Pacheco; Cordeiro, Rossana de Aguiar; Marques, Francisca Jakelyne de Farias; Brilhante, Raimunda Sâmia NogueiraThis study evaluated in vitro interactions of antituberculosis drugs and triazoles against Histoplasma capsulatum. Nine drug combinations, each including an antituberculosis drug (isoniazid, pyrazinamide, or ethambutol) plus a triazole (itraconazole, fluconazole, or voriconazole), were tested against both growth forms of H. capsulatum. Stronger synergistic interactions were seen in isoniazid or pyrazinamide plu...
Efeito inibitório in vitro de ciprofloxacina isolada e em combinação com antifú...
Caetano, Érica PachecoCoccidioidomycosis and histoplasmosis are systemic mycoses that occur in humans and other animals and are caused by the dimorphic fungi Coccidioides posadasii and Histoplasma capsulatum var. capsulatum, respectively. They are considered important deep mycoses that can lead to several secondary complications. In the past years, the improvement of the techniques applied in mycological diagnosis and the increase i...