9 documents found, page 1 of 1
In vitro inhibitory activity of terpenic derivatives against clinical and envir...
Brilhante, Raimunda Sâmia Nogueira; Marques, Natalya Fechine Silva; Castelo-Branco, Débora de Souza Collares Maia; Lima, Rita Amanda Chaves deSporotrichosis is a subacute or chronic subcutaneous infection, caused by the fungus Sporothrix schenkii complex, occurring in human and animal tissues. Potassium iodide and itraconazole have been used as effective therapy for first-choice treatment, while am- photericin B may be indicated for disseminated infection. However, the adverse effects of potassium iodide and amphotericin B or the long duration of the...
Simvastatin inhibits planktonic cells and biofilms of Candida and Cryptococcus ...
Brilhante, Raimunda Sâmia Nogueira; Caetano, Erica Pacheco; Oliveira, Jonathas Sales de; Castelo-Branco, Débora de Souza Collares MaiaThe antifungal activity of some statins against different fungal species has been reported. Thus, at the first moment, the in vitro antifungal activity of simvastatin, atorvastatin and pravastatin was tested against Candida spp. and Cryptococcus spp. Then, in a second approach, considering that the best results were obtained for simvastatin, this drug was evaluated in combination with antifungal drugs against p...
Synthesis and in vitro antifungal activity of isoniazid-derived hydrazones agai...
Cordeiro, Rossana de Aguiar; Melo, Charlline Vládia Silva de; Marques, Francisca Jakelyne de Farias; Serpa, Rosana; Evangelista, Antônio José de JesusCoccidioidomycosis is a potentially severe infection caused by dimorphic fungi Coccidioides immitis and Coccidioides posadasii . Although guidelines are well established, refractory disease is a matter of concern in the clinical management of coccidioidomycosis. In the present study three isoniazid-derived hydra- zones N 0 -[( E )-1-(4-methoxyphenyl)ethylidene]pyridine-4-carbohydrazide, N 0 -[( E )-1-(4-methylp...
Farnesol against Coccidioides posadasii : its effect on growth, ergosterol
Brilhante, Raimunda Sâmia Nogueira; Lima, Rita Amanda Chaves de; Caetano, Erica Pacheco; Leite, João Jaime GiffoniCoccidioidomycosis is a systemic mycosis caused by the dimorphic fungi Coccidioides spp. The treatment for chronic and/or disseminated coccidioidomycosis can be prolonged and complicated. Therefore, the search for new drugs is necessary. Farnesol is a precursor in the sterol biosynthesis pathway that has been shown to present antifungal activity. Thus, the objective of this study was to evaluate the in vitro an...
Effect of farnesol on growth, ergosterol biosynthesis, and cell permeability in...
Caetano, Erica Pacheco; Brilhante, Raimunda Sâmia Nogueira; Lima, Rita Amanda Chaves de; Leite, João Jaime GiffoniCoccidioidomycosis is a systemic mycosis caused by the dimorphic fungi Coccidioides spp. The treatment for chronic and/or disseminated coccidioidomycosis can be prolonged and complicated. Therefore, the search for new drugs is necessary. Farnesol is a precursor in the sterol biosynthesis pathway that has been shown to present antifungal activity. Thus, the objective of this study was to evaluate the in vitro an...
Ciprofloxacin shows synergism with classical antifungals against Histoplasma ca...
Caetano, Erica Pacheco; Brilhante, Raimunda Sâmia Nogueira; Sidrim, José Júlio Costa; Cordeiro, Rossana de Aguiar; Camargo, Zoilo Pires deThis study evaluated the in vitro interaction between ciprofloxacin (CIP) and classical antifungals against Histoplasma capsulatum var. capsulatum in mycelial (n = 16) and yeast-like forms (n = 9) and Coccidioides posadasii in mycelial form (n = 16). This research was conducted through broth microdilution and macrodilution, according to Clinical Laboratory Standards Institute. Inocula were prepared to obtain fr...
Histoplasmosis in HIV-positive patients in Ceará, Brazil : clinical-laboratory ...
Caetano, Erica Pacheco; Brilhante, Raimunda S.N.; Fechine, Maria A.B.; Mesquita, Jacó R.L.; Cordeiro, Rossana A.; Rocha, Marcos F.G.; Monteiro, André J.This study contains a descriptive analysis of histoplasmosis in AIDS patients between 2006 and 2010 in the state of Ceará, Brazil. Additionally, the in vitro susceptibility of Histoplasma capsulatum isolates obtained during this period was assessed. We report 208 cases of patients with histoplasmosis and AIDS, describing the epidemiological, clinical, laboratory and therapeutic aspects. The in vitro antifungal ...
Fungal microbiota dynamics as a postmortem investigation tool: focus on Aspergi...
Caetano, Erica Pacheco; Sidrim, José Júlio Costa; Moreira Filho, Renato Evando; Cordeiro, Rossana de Aguiar; Rocha, Marcos Fábio GadelhaAims: To investigate the presence of fungi during three human decomposition stages: bloated, putrefaction and skeletonization. Methods and Results: The samples were gathered in the city of Fortaleza, Ceara´ , Brazil, from the public morgue and cemeteries. The material was submitted to conventional mycological procedures by direct examination and macro ⁄ micro morphological and biochemical analyses. The main fun...
Trichophyton mentagrophytes perforates hair of adult corpses in the gaseous period
Caetano, Erica Pacheco; Moreira Filho, Renato Evando; Sidrim, José Júlio Costa; Cordeiro, Rossana de A.; Rocha, Marcos Fabio G.Despite the substantial literature on mycology, there are still limited reports of the interaction between fungi and human hosts in the postmortem period. Thus, the main goal of this study was to investigate the in vitro perforation test using Trichophyton mentagrophytes on hair from adult corpses in the postmortem period (gaseous period). The protocol was carried out with positive (prepubescent children’s hair...